NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

DCN1-like protein 3 - Bos taurus - NucEnvDB

DCN1-like protein 3 (Bos taurus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	DCN1-like protein 3
Accession Code	Q5E9V1
Gene	DCUN1D3
Organism	Bos taurus \| Cattle (Taxonomy: 9913)
Part of Reference Proteome?	Yes
Sequence (Length: 304)
MGQCVTKCKNPSSTLGSKNGDRDPSSKSHGRRSASHREEQLPTCGKPGGDILVNGTKKAEAAPEACQLPTSSGDAGREPKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLL AWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNY SEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q8IWE4}. Cytoplasm {By SimilarityUniProtKB:Q8IWE4}. Nucleus {By SimilarityUniProtKB:Q8IWE4}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q8IWE4}. Note=After UVC treatment, the protein enters to the nucleus gradually. Cell membrane localization is essential for CUL3 neddylation. {By SimilarityUniProtKB:Q8IWE4}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q8IWE4,}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Ubiquitin Ligase Complex (GO:0000151)

Biology & Function

Description
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. {By SimilarityUniProtKB:Q8IWE4}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Cell Growth (GO:0030308) Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle (GO:2000134) Negative Regulation Of Protein Neddylation (GO:2000435) Positive Regulation Of Apoptotic Process (GO:0043065) Positive Regulation Of Protein Neddylation (GO:2000436) Positive Regulation Of Ubiquitin-Protein Transferase Activity (GO:0051443) Protein Neddylation (GO:0045116) Regulation Of Cell Cycle Process (GO:0010564) Regulation Of Protein Neddylation (GO:2000434) Response To Gamma Radiation (GO:0010332) Response To UV-C (GO:0010225)
Molecular Function	Cullin Family Protein Binding (GO:0097602) Ubiquitin Conjugating Enzyme Binding (GO:0031624) Ubiquitin-Like Protein Binding (GO:0032182)

Cross-References

Database	Links
UNIPROT	Q5E9V1
Pfam	PF03556
PROSITE	PS51229

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