NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

RNA transcription, translation and transport factor protein - Pongo abelii - NucEnvDB

RNA transcription, translation and transport factor protein (Pongo abelii)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	RNA transcription, translation and transport factor protein
Accession Code	Q5R8I2
Gene	RTRAF
Organism	Pongo abelii \| Sumatran orangutan (Taxonomy: 9601)
Part of Reference Proteome?	Yes
Sequence (Length: 244)
MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAIDWLLGLAVRLEYGDNAEKYKDLVPDNSKTADNATKNAEPLINLDVNNPDF KAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:Q9Y224}. Cytoplasm, cytosol {By SimilarityUniProtKB:Q9Y224}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9Y224}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {By SimilarityUniProtKB:Q9Y224}. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {By SimilarityUniProtKB:Q9Y224}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Centrosome (GO:0005813) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Mitotic Spindle (GO:0072686) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) TRNA-Splicing Ligase Complex (GO:0072669)

Biology & Function

Description
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. {By SimilarityUniProtKB:Q9Y224}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Protein Kinase Activity (GO:0006469) Positive Regulation Of Transcription By RNA Polymerase II (GO:0045944) TRNA Splicing, Via Endonucleolytic Cleavage And Ligation (GO:0006388)
Molecular Function	Identical Protein Binding (GO:0042802) RNA Binding (GO:0003723) RNA Polymerase II Complex Binding (GO:0000993)

Cross-References

Database	Links
UNIPROT	Q5R8I2
Pfam	PF10036

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