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NucEnvDB
A database of Nuclear Envelope Proteins and their Interactions
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Optineurin - Danio rerio - NucEnvDB
Optineurin (
Danio rerio
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Cross-References
General Information
Protein Information
Protein Name
Optineurin
Accession Code
Q5RI56
Gene
optn
Organism
Danio rerio
| Zebrafish (Taxonomy:
7955
)
Part of Reference Proteome?
Yes
Sequence (Length: 517)
Show
MNGDISHPRGSGPGNLGSLEETLQQMNTLIKENRDLKEALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVENEALKNQVKELEKSGAECLHTELEALRGQILRIQAEKNDLVAMNS
ELQLKMGQGSPSNSFIEIRIADDDLKVTKDLSSVPEASAFSMPKAESEEQTVRQLLRSLRAETDEKERLQLTLQEARGRIAELESKLEHADSSAQTSLPSAAETNASTEVKNLEDQLLKLCNELKQAQIK
LDEAESMKRNLQDRCKDLEQDLGTLKTQLGDKQKVQAENDCLKVQMESLQAAIKLEQKKTQDEKNNLNQLKDAYTKLFEDYSELQEEKKKRESCVSKDDYDELQTRFATAEKALADKQQKIDEMKMELFQ
KEKDLETISVFQAQAEIYSSDFYAERAAREKIHEEKERLATQLEYVKKQNSQLQEEMESLGRHSMSEMQRRHVPRGANPQGPTAPNNLPGGRGEWQQQNIPDHACPKCGEVLPDLDSLQIHIMDCII
Subcellular Location
Description
Show
Cytoplasm {
By Similarity
}. Cytoplasm, perinuclear region {
By Similarity
}. Golgi apparatus {
By Similarity
|UniProtKB:Q96CV9}. Golgi apparatus, trans-Golgi network {
By Similarity
}. Cytoplasmic vesicle {
By Similarity
}. Recycling endosome {
By Similarity
}. Cytoplasmic vesicle, autophagosome {
By Similarity
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
Show
Cellular Component
Autophagosome
(
GO:0005776
)
Cytoplasm
(
GO:0005737
)
Golgi Apparatus
(
GO:0005794
)
Nucleus
(
GO:0005634
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
Recycling Endosome
(
GO:0055037
)
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Biology & Function
Description
Hide
Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. {
By Similarity
,
By Similarity
|UniProtKB:Q96CV9}.
Assigned Ontology terms
Show
Biological Process
Autophagy
(
GO:0006914
)
Axonogenesis
(
GO:0007409
)
Defense Response To Bacterium
(
GO:0042742
)
Golgi Ribbon Formation
(
GO:0090161
)
Protein Localization To Golgi Apparatus
(
GO:0034067
)
Regulation Of I-KappaB Kinase/NF-KappaB Signaling
(
GO:0043122
)
Vesicle Localization
(
GO:0051648
)
Vesicle-Mediated Transport
(
GO:0016192
)
Molecular Function
K63-Linked Polyubiquitin Modification-Dependent Protein Binding
(
GO:0070530
)
Metal Ion Binding
(
GO:0046872
)
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Cross-References
Database
Links
UNIPROT
Q5RI56
Q6P3H5
Q7SXF4
Pfam
PF16516
PF11577
PROSITE
PS51801
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory