NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Sphingomyelin phosphodiesterase 4 - Xenopus laevis - NucEnvDB

Sphingomyelin phosphodiesterase 4 (Xenopus laevis)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Sphingomyelin phosphodiesterase 4
Accession Code	Q5XHG1
Gene	smpd4
Organism	Xenopus laevis \| African clawed frog (Taxonomy: 8355)
Part of Reference Proteome?	Yes
Sequence (Length: 824)
MLLAGGSPQPSFLLGSLKADCVTKPFLQRCQDLVRVIEDFPAKELHAIFPWLIETVFGSLDGSILGWNLRGLHERINPLEFHTALEFLDPSGAMMKLVYKLQAEEYKYDFPVSFLPGPVRASIQERVLPE CPLYHNKIQFPASGGVSFNLALNSFEYFMFHFAFCLLKQRNYPQGLHFSTADSAYYILVDKYLKWFLPVEGNVPPPHSPNTGGTVPSPAPRSPSLSFTSYGSHTSLLKRHISHQHLVNADPAAQEIWRTE TLLQVFVEIWLHHYSLEMYQKMQSPNAKLEALHNRLSVSSAPPIYPALPGSLHSYQELFQPTEEHVLVVRLLVKHLHTFSNSIRPEQVSPSTHSHTASPLEELKRVVVPRFIQQKLYIFLQHCFGHWPLD ASFRAVLEMWLSYVQPWRYVLERSSPVSGEMQNRNVPEKWSTFVQENLLFYTKLFLRFLSRALRTDLVNPKNALMVFRAAKVFSQLNLPEMILNGEQLFLKPEHVIPHRQHRLLLTPNLGGSFLSSWQPP ITDTSLKVKSHVFSLEGQDCQYMQMFGPEARNLVLRLAQMISQAKQTAKSISNHSPDSSANQSFLSWFGLGSPDFNGSYNGSDLDEAGYDTIRKTDEHLEKALDYFCQIFRLNPTQLGQLTANVDSSQDD DGKNKLPDCIQSEDGVVLTSLGRYQIINGLRKFDIEYQGDPELQPIRSYENAMLVRYLYRLSSVINKRFANSMGALCARKDFLGKLCRHHLTSSSRKCKKSPITSVSPSEPAAPHIRLRFLASYRTLAFL FIFYILGSLLSLGPLICTFLLLIGCMFYAIVQTLLSEEQKPHNN

Subcellular Location

Description
Endoplasmic reticulum membrane {By SimilarityUniProtKB:Q9NXE4}; Single-pass membrane protein {Sequence Analysis}. Golgi apparatus membrane {By SimilarityUniProtKB:Q9NXE4}; Single-pass membrane protein {Sequence Analysis}. Nucleus envelope {By SimilarityUniProtKB:Q9NXE4}. Cell membrane, sarcolemma {ECO:0000250\|UniProtKB:Q6ZPR5}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Golgi Membrane (GO:0000139) Nuclear Envelope (GO:0005635) Sarcolemma (GO:0042383)

Biology & Function

Description
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. {By SimilarityUniProtKB:Q9NXE4}.
Assigned Ontology terms

Biological Process	Cellular Response To Tumor Necrosis Factor (GO:0071356) Ceramide Biosynthetic Process (GO:0046513) Sphingomyelin Catabolic Process (GO:0006685)
Molecular Function	Metal Ion Binding (GO:0046872) Sphingomyelin Phosphodiesterase Activity (GO:0004767) Sphingomyelin Phosphodiesterase D Activity (GO:0050290)

Cross-References

Database	Links
UNIPROT	Q5XHG1 Q4V7Y8
Pfam	PF14724

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