NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Eukaryotic translation initiation factor 4H - Rattus norvegicus - NucEnvDB

Eukaryotic translation initiation factor 4H (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Eukaryotic translation initiation factor 4H
Accession Code	Q5XI72
Gene	Eif4h
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 248)
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRK GGPDDRGMGGSREPRGGWDSRDDFSSGYRDDFLGGRGGSRPGDRRAGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Developmental Growth (GO:0048589) Eukaryotic Translation Initiation Factor 4F Complex Assembly (GO:0097010) Formation Of Translation Preinitiation Complex (GO:0001731) Sexual Reproduction (GO:0019953)
Molecular Function	Ribosomal Small Subunit Binding (GO:0043024) RNA Strand Annealing Activity (GO:0033592) RNA Strand-Exchange Activity (GO:0034057) Translation Initiation Factor Activity (GO:0003743)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q96RT1	Erbin	EBI-22258042	0.35
Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9UI08	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)	EBI-22238608	0.35
P27361	Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)	EBI-22238588	0.35
P15498	Proto-oncogene vav	EBI-22241288	0.35
P07332	Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)	EBI-22243434	0.35
P08069	Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]	EBI-22245613	0.35
P18031	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)	EBI-22255654	0.35
O75096	Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)	EBI-22258804	0.35

Cross-References

Database	Links
UNIPROT	Q5XI72
Pfam	PF00076
PROSITE	PS50102

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