NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Kelch-like protein 20 - Gallus gallus - NucEnvDB

Kelch-like protein 20 (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Kelch-like protein 20
Accession Code	Q5ZKD9
Gene	KLHL20
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 610)
MDGKPMRRCTSTRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQ ITVEEGNVQTSLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRL PLLSTKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKT NQWSSDVAPTSTCRTSVGVAVLGGYLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTT ELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Nucleus {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cul3-RING Ubiquitin Ligase Complex (GO:0031463) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471) PML Body (GO:0016605) Trans-Golgi Network (GO:0005802)

Biology & Function

Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Golgi To Endosome Transport (GO:0006895) Negative Regulation Of Apoptotic Process (GO:0043066) Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process (GO:0043161) Protein K33-Linked Ubiquitination (GO:1990390) Protein Transport (GO:0015031) Protein Ubiquitination (GO:0016567)
Molecular Function	Type II Interferon Binding (GO:0019964) Ubiquitin-Protein Transferase Activity (GO:0004842)

Cross-References

Database	Links
UNIPROT	Q5ZKD9
Pfam	PF07707 PF00651 PF01344
PROSITE	PS50097

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