National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Adenosine monophosphate-protein hydrolase SidD |
| Accession Code | Q5ZSQ2 |
| Gene | sidD |
| Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 (Taxonomy: 272624) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 507) |
Structure Viewer (PDB: 4IIP) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Host Perinuclear Region | SL-0382 | The host perinuclear region is the host cytoplasmic region just around the host nucleus. Note: This location is defined for viral proteins that appear in the perinuclear region of infected host cells | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De- AMPylation of RAB1B cannot take place when LidA is bound to RAB1B. {Experimental EvidencePubMed:21680813, Experimental EvidencePubMed:21734656, Experimental EvidencePubMed:22228731}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory