NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Guanylate-binding protein 4 - Mus musculus - NucEnvDB

Guanylate-binding protein 4 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Guanylate-binding protein 4
Accession Code	Q61107
Gene	Gbp4
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 620)
MEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINQ QALEQLHFVTELTQLIRAKSSPREDKVKDSSEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLLLQIENVPENQLERNFQVESE KFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERKEEFIR QNEAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKAKEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKEQEQVMEAQERSFREN IAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLKNEISHLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSLSS

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q96PP9}. Nucleus {By SimilarityUniProtKB:Q96PP9}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q96PP9}. Golgi apparatus membrane {By SimilarityUniProtKB:Q96PP9}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. {By SimilarityUniProtKB:Q96PP9}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasmic Vesicle (GO:0031410) Cytosol (GO:0005829) Golgi Apparatus (GO:0005794) Golgi Membrane (GO:0000139) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Symbiont-Containing Vacuole Membrane (GO:0020005)

Biology & Function

Description
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. {Experimental EvidencePubMed:9659399}.
Assigned Ontology terms

Biological Process	Adhesion Of Symbiont To Host (GO:0044406) Cellular Response To Interferon-Beta (GO:0035458) Cellular Response To Type II Interferon (GO:0071346) Cellular Response To Tumor Necrosis Factor (GO:0071356) Defense Response To Gram-Positive Bacterium (GO:0050830) Defense Response To Protozoan (GO:0042832) Defense Response To Virus (GO:0051607) Negative Regulation Of Cytokine Production (GO:0001818) Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT (GO:0046426) Negative Regulation Of Type I Interferon Production (GO:0032480) Negative Regulation Of Type III Interferon Production (GO:0034345) Positive Regulation Of Viral Genome Replication (GO:0045070) Regulation Of I-KappaB Kinase/NF-KappaB Signaling (GO:0043122)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Identical Protein Binding (GO:0042802) Protein Homodimerization Activity (GO:0042803)

Cross-References

Database	Links
UNIPROT	Q61107 Q8VEC5
Pfam	PF02263 PF02841
PROSITE	PS51715

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