NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Glycerophosphodiester phosphodiesterase domain-containing protein 5 - Mus musculus - NucEnvDB

Glycerophosphodiester phosphodiesterase domain-containing protein 5 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Glycerophosphodiester phosphodiesterase domain-containing protein 5
Accession Code	Q640M6
Gene	Gdpd5
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 607)
MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLVCTFSLTLTWLYFWWGVHNDYDEFNWYLYNRMGYWSDWSVPILVTSAAAFTYIAGLLVLALCHIAVGQQLNLHWIHKMGLVV ILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHIGALVAITALSWIVAGQFARAERSSSQLTILCTFFAVVFTFYLIPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTVMSFRKALEQRLYGLQ ADITISLDGVPFLMHDTTLRRTTNVEHLFPELARRPAAMLNWTVLQRLNAGQWFLKTDPFWTASSLSPSDHREVQNQSICSLAELLELAKGNASLLLNLRDPPRDHPYRGSFLNVTLEAVLRSGFPQHQV MWLFNRQRPLVRKMAPGFQQTSGSKEAIANLRKGHIQKLNLRYTQVSHQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHTLSRVPSPLWIMPPDEYCLMWVTADLISFSLIIGIFVLQKW RLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSDELSVCSDSSYDTYANANSTATPVGPRNAGSRAKTVTEQSGH

Subcellular Location

Description
Endomembrane system {Experimental EvidencePubMed:17275818, Experimental EvidencePubMed:18667693, Curator InferencePubMed:15276213}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:15276213, Experimental EvidencePubMed:17275818, Experimental EvidencePubMed:18667693}. Cell projection, growth cone {Experimental EvidencePubMed:17275818}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Endoplasmic Reticulum Membrane (GO:0005789) Growth Cone (GO:0030426) Membrane (GO:0016020) Neuronal Cell Body (GO:0043025) Perinuclear Endoplasmic Reticulum (GO:0097038) Plasma Membrane (GO:0005886)

Biology & Function

Description
Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (PubMed:17275818, PubMed:18667693). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (PubMed:18667693). {By SimilarityUniProtKB:Q3KTM2, Experimental EvidencePubMed:17275818, Experimental EvidencePubMed:18667693}.
Assigned Ontology terms

Biological Process	Cerebral Cortex Neuron Differentiation (GO:0021895) Lipid Metabolic Process (GO:0006629) Negative Regulation Of Notch Signaling Pathway (GO:0045746) Neuron Differentiation (GO:0030182) Neuron Projection Development (GO:0031175) Notch Signaling Pathway (GO:0007219) Positive Regulation Of Cell Cycle (GO:0045787) Positive Regulation Of Neuron Differentiation (GO:0045666) Regulation Of Timing Of Cell Differentiation (GO:0048505) Spinal Cord Motor Neuron Differentiation (GO:0021522)
Molecular Function	Glycerophosphocholine Phosphodiesterase Activity (GO:0047389) Glycerophosphodiester Phosphodiesterase Activity (GO:0008889) Phosphatidylinositol Phospholipase C Activity (GO:0004435)

Cross-References

Database	Links
UNIPROT	Q640M6 Q8R0T5 Q8R3N5
Pfam	PF03009
PROSITE	PS51704

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