NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Alpha-protein kinase vwkA - Dictyostelium discoideum - NucEnvDB

Alpha-protein kinase vwkA (Dictyostelium discoideum)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Alpha-protein kinase vwkA
Accession Code	Q6B9X6
Gene	vwkA
Organism	Dictyostelium discoideum (Taxonomy: 44689)
Part of Reference Proteome?	Yes
Sequence (Length: 625)
MESKYVLSTEKESKTKPSGRVNVSDMDSISNSLSKTSLGTRKVPTSLKTDASRSGLSSGGSKTHISDESALRMVYGSTPRDEKTTTTKDSITLAKEKEKKIEKRNEEIKLTFKAIRASECVDLLFIVDCT GSMDPYIEQIKSDIVKLQEALKLKHSFLDIEFGFIRYTDFDVASNRCSTFQFSRSTVEFVRFVSEIRAGGGADGPEDVFGGMDLIKSMKWRPNSTRVVIHIADAPCHGTEYHSMADSYPGGDPNGIKLDD LLTDIISLNINYYFGHINLKETGQMIDFFDKKTKEISRNKKSINSFDSKETSKMNERIFISIEESISVSRSVLTEQYLGHNIDGSTGKQRSEREFEINTNMDIDFGELPYIQMLQTKFKMPSDIVTCLSS SYEMKLNEITISIKIAPNPFSHGACRLAYLGIDEHGKKVVLKQSKYIGGRENSKKRYFESMECQTVAAKFALEFNKQLSLTSSEHQITFTVAKVLQMKHSEKPMYFGIETFINGEYQKYNSNCGWLKDDA MSEILQTFSHWTYQESKNKAIVVDIQGVKTSKGYLLTDPAIHSTDTLRFGSCNLGKPGIIKFFQSHKCNQHCKKLGLTIPSFTSSSSTSSSSRSTSSSSSISYSY

Subcellular Location

Description
Cytoplasm, cytosol {Experimental EvidencePubMed:15728726}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:15728726}. Contractile vacuole membrane {Experimental EvidencePubMed:15728726}. Note=Enriched adjacent to large spherical structures such as contractile vacuoles and Golgi-like structures (perinuclear).
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Contractile Vacuolar Membrane (GO:0031164) Contractile Vacuole (GO:0000331) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Displays a modest preference for threonine over serine residues. Does not phosphorylate myosin II, however can phosphorylate MBP, in vitro. May be involved in the regulation of myosin II function during cytokinesis. Overexpression leads to impaired cell proliferation in suspension culture and fails to develop beyond the mound stage. Both overexpression and absence of the gene can result in defects in cytokinesis and alterations in myosin II abundance and assembly. {Experimental EvidencePubMed:15728726, Experimental EvidencePubMed:18381083}.
Assigned Ontology terms

Biological Process	Contractile Vacuole Discharge (GO:0070177) Contractile Vacuole Organization (GO:0033298) Hypotonic Response (GO:0006971) Mitotic Cytokinesis (GO:0000281) Myosin II Filament Organization (GO:0031038) Peptidyl-Serine Modification (GO:0018209) Protein Phosphorylation (GO:0006468) Regulation Of Sorocarp Development (GO:0031156) Sorocarp Morphogenesis (GO:0031288)
Molecular Function	ATP Binding (GO:0005524) Calmodulin Binding (GO:0005516) Protein Kinase Activity (GO:0004672) Protein Serine Kinase Activity (GO:0106310) Protein Serine/Threonine Kinase Activity (GO:0004674)

Cross-References

Database	Links
UNIPROT	Q6B9X6 Q55FF0
Pfam	PF02816
PROSITE	PS51158

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