NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein unc-45 homolog B - Danio rerio - NucEnvDB

Protein unc-45 homolog B (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein unc-45 homolog B
Accession Code	Q6DGE9
Gene	unc45b
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 934)
MTMGEIGDSVQLKEEGNKHFQAGEIDQAIDCYTKAIKTCKKEDKKALAVIYRNRSACFLKKENYSNAASDATKAIDVDAADIKALYRRCQAFEKLGKLDMAFKDVQRCATIEPKNKTFLETLRRLGAEIQ QKLKTTFSTDSRVQNMFDILFSDEPDKEKREKAANNLIVLAREDAGAERIFQNNGVPLLMQLIDTGKPEMILAAIRTLSGMCTGHRARATAIIHSVGISKLCSIMAVDNEEIALATANLFQCVNDSLSGG DKRNYGKEEALVLDSSKDLKDILLALLEMIASKNVSGHGRDQALNLLTKNVPRQNKKSTDNSKCLFTIDHGLKKILKVCGQVPDLPDQLPMTENTQLIASVLLSKLYDDLRCDPERDQFRDICDDYIKSK FDPNDMDKNIHAINTLSGILQGPFDLGNVLAGRQGVMEMMVALCGSEREVDQLVAVEALIHASTKTSKASFFISNGVSLLKEMYKKTKNEKIKIRALVGLCKLGSAGGDDYSMRQFAEGSTEKLAKQCRK WLCNPTLDVRTRKWAIEGLAYLTNDADVKDDFAEDEPAMRAMFELTKSNDKTILYAVACTLVNCTNSYDKKEIIPEMVQLAKFSKQHVPEQHPKDKKDFIVRRVKRLLKAGVTSALAVMVKADNSILTDQ TKEMLARVFLALTEDVKDRGIIVAQGGGKALIPLALEGTDKGKIKASHALAKIAAVSNPEIAFPGERIYEVVRPLVSLLGTDRDGMENFEALRGLTNLAGLNDKLRVKILKEKALPEIENYMFEDHEQIR QAATECMCNLVCCKEVQDRYLEDGNDKLKLLVLLCGEDEEKLQRAAAGALAMLTAAQKKLAVKMTKVTEQWLEILQRLCIHDNPEIQHRGLVTVFNMLDADDQLAKKLVESDMLEILTYVAKLEDNPKKQ NAIDAARACLSKAMDNGLIKPFSN

Subcellular Location

Description
Cytoplasm, myofibril, sarcomere, Z line {Experimental EvidencePubMed:18347070, Experimental EvidencePubMed:20440001}. Cytoplasm, myofibril, sarcomere, A band {Experimental EvidencePubMed:18347070, Experimental EvidencePubMed:20440001}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:18347070, Experimental EvidencePubMed:20440001}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {Experimental EvidencePubMed:18347070, Experimental EvidencePubMed:20440001}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	A Band (GO:0031672) Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471) Z Disc (GO:0030018)

Biology & Function

Description
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development (PubMed:17189627, PubMed:17586488, PubMed:20440001, PubMed:20849610). Is necessary for normal early lens development (PubMed:24549050). {By SimilarityUniProtKB:Q8CGY6, Experimental EvidencePubMed:17189627, Experimental EvidencePubMed:17586488, Experimental EvidencePubMed:20440001, Experimental EvidencePubMed:20849610, Experimental EvidencePubMed:24549050}.
Assigned Ontology terms

Biological Process	Cardiac Muscle Tissue Development (GO:0048738) Chaperone-Mediated Protein Folding (GO:0061077) Lens Development In Camera-Type Eye (GO:0002088) Myofibril Assembly (GO:0030239) Skeletal Muscle Organ Development (GO:0060538) Skeletal Muscle Tissue Development (GO:0007519)
Molecular Function	Hsp90 Protein Binding (GO:0051879)

Cross-References

Database	Links
UNIPROT	Q6DGE9 Q8UVX6
Pfam	PF11701
PROSITE	PS50293

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