NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Exocyst complex component 3 - Mus musculus - NucEnvDB

Exocyst complex component 3 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Exocyst complex component 3
Accession Code	Q6KAR6
Gene	Exoc3
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 755)
MCKDSACFLTMKETDLEAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIF SVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMCEQYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFA ILDRTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTRMQDLASEDLEANEIVSLLTWVLNTYTSAEMMGNVELAPEVDVSALEPLLSPNIVSELL DTYMSTLTSNIIAWLRKALETDKKDWSKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHCYVQYMIAIINNCQTFKESIISLKRK YLKTEAEEGLCLSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHLNELMTKKWLLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSAEERKEGAEKMVREAEQLRFL FRKLASGFGEDADGHCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLALRGDASRDMKQTIMETLEQGPMQASPNYVPIFKEIVVPSLNVAKLLK

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:O54921}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O54921}. Cell projection, growth cone {By SimilarityUniProtKB:O54921}. Midbody {ECO:0000250\|UniProtKB:O60645}. Golgi apparatus {ECO:0000250\|UniProtKB:O60645}. Cell projection, neuron projection {ECO:0000250\|UniProtKB:Q62825}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB- dependent (By similarity). {By SimilarityUniProtKB:O54921, ECO:0000250\|UniProtKB:O60645}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Exocyst (GO:0000145) Golgi Apparatus (GO:0005794) Growth Cone (GO:0030426) Midbody (GO:0030496) Perinuclear Region Of Cytoplasm (GO:0048471) Presynaptic Membrane (GO:0042734) Secretory Granule Membrane (GO:0030667)

Biology & Function

Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {By Similarity}.
Assigned Ontology terms

Biological Process	Exocyst Localization (GO:0051601) Exocytosis (GO:0006887) Membrane Fission (GO:0090148) Mitotic Cytokinesis (GO:0000281) Protein Transport (GO:0015031) Vesicle Docking Involved In Exocytosis (GO:0006904) Vesicle Tethering Involved In Exocytosis (GO:0090522)
Molecular Function	SNARE Binding (GO:0000149)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P25322	G1/S-specific cyclin-D1	EBI-3956307	0.46
Interactions with other proteins (4 interactors)

Partner (UniProt)		IntAct	Confidence score
O35382	Exocyst complex component 4 (Exocyst complex component Sec8)	EBI-8299949	0.40
P23819	Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)	EBI-8300089	0.40
P35438	Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)	EBI-8300130	0.40
P11234	Ras-related protein Ral-B (EC 3.6.5.2)	EBI-3956345	0.27

Cross-References

Database	Links
UNIPROT	Q6KAR6
Pfam	PF06046

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