NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase SH3RF1 - Xenopus laevis - NucEnvDB

E3 ubiquitin-protein ligase SH3RF1 (Xenopus laevis)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase SH3RF1
Accession Code	Q6NRD3
Gene	sh3rf1
Organism	Xenopus laevis \| African clawed frog (Taxonomy: 8355)
Part of Reference Proteome?	Yes
Sequence (Length: 826)
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVSSRKELRCPECRTLVECGVDELPSNILLVRLLDGIRQRPRKAGDGGSAGNSTNALRAQGSVTTNGGLNDAQNTQSGQQRIQARSPPVRG VPQLPCAKALYNYEGKEPGDLKFNKGDIIVLRRQVDENWYHGEINGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFLKDDILTVIRRVDENWAEGMLGDKIGIFPISYVEFNSAAKQ LIELDKPSGADTGEGSSGTSHSGNSQKQADAKKNTKKRHSFTSLTMSNKSSQSVQNRHSMEISPPVLISSSNPTAAARISELTGLSCSAPSQDMNPPLLPPPPMATPVITSASSGAAAVAQRNIIGPVEQ VPHLRTSARPSVFIAIYPYIPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRALTTATPAKVAMATATTSNVVNLVTPTPPGAPCQKLPVSGVEFAKTSSTNGVSPAGVPGCH IQTSPQSKVLLHMSGQMTVNQARNAVRTAAAHSQDRPTAAVTPIQAQTPAASALPQQAAASQQVPPPLSAPAAYINAAMNISRPSVPAASAASSALPTAAFEAESSWKSSSGLSGCSFSENVSAPLNSAA NKQDKDSKKEKKGLLKLLSGASTKRKPRSSPPHSPTQEVEQTNSEAAAALEGAVGPDIVPVIVNGRAAPCTVDCDSVSASTPAQDNRKPASLDNNIPIAPPPRQPCSSLGSVLNDSRPCERYRVMVSYPP QSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q71F54}. Cell projection, lamellipodium {By SimilarityUniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {By SimilarityUniProtKB:Q69ZI1}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Golgi Apparatus (GO:0005794) Lamellipodium (GO:0030027) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway (By similarity). Plays an essential role in the anterior neural development. {By SimilarityUniProtKB:Q69ZI1, By SimilarityUniProtKB:Q7Z6J0, Experimental EvidencePubMed:16125690}.
Assigned Ontology terms

Biological Process	Neuron Migration (GO:0001764) Positive Regulation Of JNK Cascade (GO:0046330) Protein Autoubiquitination (GO:0051865) Regulation Of CD4-Positive, Alpha-Beta T Cell Differentiation (GO:0043370) Regulation Of CD8-Positive, Alpha-Beta T Cell Proliferation (GO:2000564)
Molecular Function	MAP-Kinase Scaffold Activity (GO:0005078) Metal Ion Binding (GO:0046872) Ubiquitin Protein Ligase Activity (GO:0061630)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8QHK8	Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1)	EBI-7734026	0.40
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)	EBI-7734085	0.40

Cross-References

Database	Links
UNIPROT	Q6NRD3 Q3L1I1
Pfam	PF00018 PF14604 PF00097
PROSITE	PS50002 PS00518 PS50089

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK