NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Exocyst complex component 8 - Mus musculus - NucEnvDB

Exocyst complex component 8 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Exocyst complex component 8
Accession Code	Q6PGF7
Gene	Exoc8
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 716)
MSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRVQALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLALLPAAAAGASAGEDTAGAGPRERGAVQAGF LPGPAGVPREGSGTGEEGKQRTLTTLLEKVEGCRDLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYPLDRLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKI KREWLEVLEETKRALSDKRRREQEEAAAPRAPPPVTSKGSNPFEDEDDEELATPEAEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPPVKELRAKVDERVRQLTEVLVFELS PDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFETDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHC QQLGEIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEIILVAVQHVD YSLRCEQDPEKKAFIRQNASFLYETVLPVVERRFEEGVGKPAKQLQDLRNASRLLRVNPESTTSVV

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:O54924}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O54924}. Cell projection, growth cone {By SimilarityUniProtKB:O54924}. Cell projection {By SimilarityUniProtKB:O54924}. Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, By SimilarityUniProtKB:O54924}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Leading Edge (GO:0031252) Exocyst (GO:0000145) Growth Cone (GO:0030426) Late Endosome (GO:0005770) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {By Similarity}.
Assigned Ontology terms

Biological Process	Endosome Organization (GO:0007032) Exocytosis (GO:0006887) Extracellular Matrix Disassembly (GO:0022617) Golgi To Plasma Membrane Transport (GO:0006893) Membrane Fission (GO:0090148) Mitotic Cytokinesis (GO:0000281) Protein Localization (GO:0008104) Protein Transport (GO:0015031) Vesicle Docking Involved In Exocytosis (GO:0006904) Vesicle Tethering Involved In Exocytosis (GO:0090522)
Molecular Function	Phosphatidylinositol Binding (GO:0035091) Small GTPase Binding (GO:0031267)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q91VJ1	Interferon-inducible protein AIM2 (Interferon-inducible protein 210) (Ifi-210) (Interferon-inducible protein p210)	EBI-6253412	0.27
Q9EPB4	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein)	EBI-6253421	0.27

Cross-References

Database	Links
UNIPROT	Q6PGF7
Pfam	PF16528
PROSITE	PS50003

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