Cytoplasmic FMR1-interacting protein 1 - Mus musculus

Cytoplasmic FMR1-interacting protein 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Cytoplasmic FMR1-interacting protein 1
Accession Code	Q7TMB8
Gene	Cyfip1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1253)
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQR NAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEK HMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCASSSSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKL FDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCD WETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTD HILETKEASMMEYVLYSLDLYNDSAHYALTKFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL ELAIGRFESEDLTSVVELDGLLEINRMTHKLLSRYLTLDSFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVG PPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQSLSLEEVCDLLHAAPFQNILPRIHVKEG ERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQ QRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:11438699, Experimental EvidencePubMed:14765121}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:11438699}. Cell projection, lamellipodium {Experimental EvidencePubMed:14765121}. Cell projection, ruffle {Experimental EvidencePubMed:14765121}. Synapse, synaptosome {Experimental EvidencePubMed:11438699}. Note=Highly expressed in the perinuclear region (PubMed:11438699). Enriched in synaptosomes (PubMed:11438699). Also enriched in membrane ruffles and at the tips of lamellipodia (PubMed:14765121). {Experimental EvidencePubMed:11438699, Experimental EvidencePubMed:14765121}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Axonal Growth Cone (GO:0044295) Central Region Of Growth Cone (GO:0090724) Cytoplasm (GO:0005737) Dendritic Growth Cone (GO:0044294) Dendritic Spine (GO:0043197) Excitatory Synapse (GO:0060076) Filopodium Tip (GO:0032433) Lamellipodium (GO:0030027) MRNA Cap Binding Complex (GO:0005845) Neuron Projection (GO:0043005) Neuronal Cell Body (GO:0043025) Perinuclear Region Of Cytoplasm (GO:0048471) Peripheral Region Of Growth Cone (GO:0090725) Postsynapse (GO:0098794) Ruffle (GO:0001726) SCAR Complex (GO:0031209) Synapse (GO:0045202) Terminal Bouton (GO:0043195)

Biology & Function

Description
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E- FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). {By SimilarityUniProtKB:Q7L576, Experimental EvidencePubMed:11438699, Experimental EvidencePubMed:14765121, Experimental EvidencePubMed:18805096, Experimental EvidencePubMed:19524508, Experimental EvidencePubMed:27605705}.
Assigned Ontology terms

Biological Process	Axon Extension (GO:0048675) Axon Guidance (GO:0007411) Cell Morphogenesis (GO:0000902) Cell Projection Assembly (GO:0030031) Cellular Response To Insulin Stimulus (GO:0032869) Cognition (GO:0050890) Dendrite Extension (GO:0097484) Lamellipodium Assembly (GO:0030032) Modification Of Synaptic Structure (GO:0099563) Negative Regulation Of Synaptic Vesicle Recycling (GO:1903422) Neuron Projection Development (GO:0031175) Positive Regulation Of Arp2/3 Complex-Mediated Actin Nucleation (GO:2000601) Positive Regulation Of Axon Extension (GO:0045773) Positive Regulation Of Axonogenesis (GO:0050772) Positive Regulation Of Dendrite Development (GO:1900006) Positive Regulation Of Lamellipodium Assembly (GO:0010592) Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway (GO:0051388) Positive Regulation Of Ruffle Assembly (GO:1900029) Rac Protein Signal Transduction (GO:0016601) Regulation Of Actin Filament Polymerization (GO:0030833) Regulation Of Cell Shape (GO:0008360) Regulation Of Modification Of Postsynaptic Actin Cytoskeleton (GO:1905274) Regulation Of Myelination (GO:0031641) Regulation Of Translation (GO:0006417) Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission (GO:0099578) Response To Electrical Stimulus (GO:0051602) Ruffle Organization (GO:0031529)
Molecular Function	Actin Filament Binding (GO:0051015) Profilin Binding (GO:0005522) RNA 7-Methylguanosine Cap Binding (GO:0000340) Small GTPase Binding (GO:0031267) Translation Regulator Activity (GO:0045182)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (10 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O08788	Dynactin subunit 1	EBI-16727444	0.35
P15209	BDNF/NT-3 growth factors receptor	EBI-16727444	0.35
P16054	Protein kinase C epsilon type	EBI-16727444	0.35
P35922	Fragile X messenger ribonucleoprotein 1	EBI-2000004	0.58
P63318	Protein kinase C gamma type	EBI-16727444	0.35
Q06787	Fragile X messenger ribonucleoprotein 1	EBI-3649150	0.37
Q5SQX6	Cytoplasmic FMR1-interacting protein 2	EBI-16727444	0.35
Q6ZPE2	Myotubularin-related protein 5	EBI-16727444	0.35
Q8CHG7	Rap guanine nucleotide exchange factor 2	EBI-16727444	0.35
P61205	ADP-ribosylation factor 3	EBI-16727444	0.35
Interactions with other proteins (115 interactors)

Partner (UniProt)		IntAct	Confidence score
P62158	Calmodulin-1	EBI-911456	0.35
P63073	Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit)	EBI-2000004	0.63
O55135	Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP))	EBI-2000004	0.40
P62754	40S ribosomal protein S6 (Phosphoprotein NP33)	EBI-2000004	0.40
Q8BM65	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	EBI-7448021	0.35
P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)	EBI-7448114	0.46
Q8R5H6	Actin-binding protein WASF1 (Protein WAVE-1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	EBI-7448095	0.53
Q5DU14	Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16)	EBI-7448718	0.35
Q80TE2	MKIAA1400 protein	EBI-9214306	0.35
Q6ZPJ3	(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)	EBI-16727444	0.35
Q8C7R4	Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)	EBI-16727444	0.35
Q9QUQ5	Short transient receptor potential channel 4 (TrpC4) (Capacitative calcium entry channel Trp4) (Receptor-activated cation channel TRP4)	EBI-16727444	0.35
Q9CQE1	Protein NipSnap homolog 3B (NipSnap3B) (NipSnap-related protein) (Protein NipSnap homolog 3A) (NipSnap3A)	EBI-16727444	0.35
P61358	60S ribosomal protein L27	EBI-16727444	0.35
Q62159	Rho-related GTP-binding protein RhoC (Silica-induced gene 61 protein) (SIG-61)	EBI-16727444	0.35
Q921J2	GTP-binding protein Rheb (Ras homolog enriched in brain)	EBI-16727444	0.35
O35239	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)	EBI-16727444	0.35
P48437	Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)	EBI-16727444	0.35
Q8C167	Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like)	EBI-16727444	0.35
Q80U63	Mitofusin-2 (EC 3.6.5.-) (Hypertension-related protein 1) (Mitochondrial assembly regulatory factor) (HSG protein) (Transmembrane GTPase MFN2)	EBI-16727444	0.35
Q03717	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab)	EBI-16727444	0.35
Q8VI75	Importin-4 (Imp4) (Importin-4a) (Imp4a) (Ran-binding protein 4) (RanBP4)	EBI-16727444	0.35
P24547	Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II)	EBI-16727444	0.35
Q9R0I7	YLP motif-containing protein 1 (Nuclear protein ZAP3)	EBI-16727444	0.35
Q9R1R2	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1)	EBI-16727444	0.35
O55013	Trafficking protein particle complex subunit 3 (BET3 homolog)	EBI-16727444	0.35
Q9CYZ2	Tumor protein D54 (Tumor protein D52-like 2)	EBI-16727444	0.35
B2RWJ3	Transmembrane protein 240	EBI-16727444	0.35
Q8CC35	Synaptopodin	EBI-16727444	0.35
F6SEU4	Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)	EBI-16727444	0.53
Q68FG2	Spectrin beta chain	EBI-16727444	0.35
Q62261	Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain)	EBI-16727444	0.35
P16546	Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)	EBI-16727444	0.35
Q61548	Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)	EBI-16727444	0.35
Q8JZR6	Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)	EBI-16727444	0.35
Q4ACU6	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)	EBI-16727444	0.35
D3YZU1	SH3 and multiple ankyrin repeat domains protein 1 (Shank1)	EBI-16727444	0.35
Q8VD37	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)	EBI-16727444	0.35
Q8K0T0	Reticulon-1 (Neuroendocrine-specific protein)	EBI-16727444	0.35
Q8BSK8	Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (S6K) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)	EBI-16727444	0.35
P63001	Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)	EBI-16727444	0.35
P68404	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	EBI-16727444	0.35
P63087	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)	EBI-16727444	0.35
Q7M6Y3	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM)	EBI-16727444	0.35
E9Q3L2	Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67)	EBI-16727444	0.35
Q2M3X8	Phosphatase and actin regulator 1	EBI-16727444	0.35
O89084	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53)	EBI-16727444	0.35
Q9WU78	Programmed cell death 6-interacting protein (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (E2F1-inducible protein) (Eig2)	EBI-16727444	0.35
O88643	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) (p21-activated kinase 1) (PAK-1) (p65-PAK)	EBI-16727444	0.35
Q9Z1M0	P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)	EBI-16727444	0.35
P58281	Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Large GTP-binding protein) (LargeG) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like 120 kDa protein, form S1]	EBI-16727444	0.35
O08919	Numb-like protein	EBI-16727444	0.35
P46460	Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Suppressor of K(+) transport growth defect 2) (Protein SKD2) (Vesicular-fusion protein NSF)	EBI-16727444	0.35
Q11011	Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)	EBI-16727444	0.35
P08553	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	EBI-16727444	0.35
P08551	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	EBI-16727444	0.35
P19246	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	EBI-16727444	0.35
P28660	Nck-associated protein 1 (NAP 1) (Brain protein H19) (MH19) (Membrane-associated protein HEM-2) (p125Nap1)	EBI-16727444	0.35
Q9Z0E0	Neurochondrin (M-Sema F-associating protein of 75 kDa) (Norbin)	EBI-16727444	0.35
P55066	Neurocan core protein (Chondroitin sulfate proteoglycan 3)	EBI-16727444	0.35
Q99104	Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle)	EBI-16727444	0.35
Q8K310	Matrin-3	EBI-16727444	0.35
Q9QXZ0	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4 (Actin cross-linking family 7)	EBI-16727444	0.35
Q8BHA1	Leucine-rich repeat-containing protein 24	EBI-16727444	0.35
P28740	Kinesin-like protein KIF2A (Kinesin-2)	EBI-16727444	0.35
Q8R0S2	IQ motif and SEC7 domain-containing protein 1	EBI-16727444	0.35
P35436	Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)	EBI-16727444	0.35
Q921M4	Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130)	EBI-16727444	0.35
P15105	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)	EBI-16727444	0.35
Q8K1B8	Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2)	EBI-16727444	0.35
F8VPU2	FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1)	EBI-16727444	0.35
Q8BWY3	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1)	EBI-16727444	0.35
Q6PH08	ERC protein 2 (CAZ-associated structural protein 1) (CAST1)	EBI-16727444	0.35
Q9WV92	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]	EBI-16727444	0.35
Q9Z2H5	Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)	EBI-16727444	0.35
P62631	Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)	EBI-16727444	0.35
Q9JHU4	Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)	EBI-16727444	0.35
Q9R0P5	Destrin (Actin-depolymerizing factor) (ADF) (Sid 23)	EBI-16727444	0.35
O35098	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4)	EBI-16727444	0.35
O08553	Dihydropyrimidinase-related protein 2 (DRP-2) (Unc-33-like phosphoprotein 2) (ULIP-2)	EBI-16727444	0.35
Q8BZ98	Dynamin-3 (EC 3.6.5.5)	EBI-16727444	0.35
P39054	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM)	EBI-16727444	0.35
Q8K1M6	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1)	EBI-16727444	0.35
P39053	Dynamin-1 (EC 3.6.5.5)	EBI-16727444	0.35
Q80TZ3	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6)	EBI-16727444	0.35
Q62108	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	EBI-16727444	0.35
Q91XM9	Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)	EBI-16727444	0.35
Q9JLM8	Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)	EBI-16727444	0.35
Q9QXS6	Drebrin (Developmentally-regulated brain protein)	EBI-16727444	0.35
Q9JLV5	Cullin-3 (CUL-3)	EBI-16727444	0.35
P97427	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)	EBI-16727444	0.35
O54991	Contactin-associated protein 1 (Caspr) (Caspr1) (MHDNIV) (NCP1) (Neurexin IV) (Neurexin-4) (Paranodin)	EBI-16727444	0.35
P80318	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5)	EBI-16727444	0.35
P47754	F-actin-capping protein subunit alpha-2 (CapZ alpha-2)	EBI-16727444	0.35
Q3UHL1	CaM kinase-like vesicle-associated protein	EBI-16727444	0.35
P28652	Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)	EBI-16727444	0.35
P11798	Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)	EBI-16727444	0.35
Q8BKX1	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)	EBI-16727444	0.35
P59999	Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)	EBI-16727444	0.35
Q60875	Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (LBC'S first cousin) (Lymphoid blast crisis-like 1) (Oncogene LFC) (Rhobin)	EBI-16727444	0.35
Q9DBG3	AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)	EBI-16727444	0.35
P17426	AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)	EBI-16727444	0.35
P61967	AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)	EBI-16727444	0.35
O35643	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	EBI-16727444	0.35
Q99NH0	Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein)	EBI-16727444	0.35
Q8C8R3	Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin)	EBI-16727444	0.35
Q3UHD9	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)	EBI-16727444	0.53
P60710	Actin, cytoplasmic 1 (Beta-actin) (EC 3.6.4.-) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	EBI-16727444	0.35
Q8CBW3	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)	EBI-16727444	0.35
Q3UHJ0	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	EBI-16727444	0.35
Q9WV60	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	EBI-16727444	0.35
Q9QYS2	Metabotropic glutamate receptor 3 (mGluR3)	EBI-16727444	0.35
P83510	Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)	EBI-16734044	0.35
Q9EP53	Hamartin (Tuberous sclerosis 1 protein homolog)	EBI-16734894	0.35
Q9D415	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)	EBI-16725590	0.35

Cross-References

Database	Links
UNIPROT	Q7TMB8 O88558 Q3U7Q7 Q5DU50 Q7TSZ5 Q80VN6 Q8CE85 Q99LY1
Pfam	PF07159 PF05994

Cytoplasmic FMR1-interacting protein 1 (Mus musculus)

General Information

Protein Information

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (10 interactors)

Interactions with other proteins (115 interactors)

Cross-References

Database

Links

Description

Description