National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Matrix protein |
| Accession Code | Q8B0H2 |
| Gene | M |
| Organism | Vesicular stomatitis Indiana virus (strain 94GUB Central America) (Taxonomy: 434489) |
| Part of Reference Proteome? | No |
| Sequence (Length: 229) |
Structure Viewer (PDB: 1LG7) |
|---|
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Host Nuclear Envelope | SL-0415 | The host nuclear envelope is a membrane system which surrounds the host nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the host nuclear intermembrane space. Note: This location is defined for viral proteins that appear in the Nuclear Envelope of infected host cells |
| Host Nuclear Membrane | SL-0418 | The membrane surrounding the host nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer host nuclear membrane. Note: This location is defined for viral proteins that appear in the Nuclear Membrane of infected host cells | Membrane Topology |
| Topology | Source | Annotation Type |
| Peripheral | UniProt | By Similarity {ECO:0000250|UniProtKB:P03519} | Assigned Ontology terms |
Description |
|
|---|---|
| Plays a major role in assembly and budding of virion, by recruiting cellular partners of the ESCRT complexes that play a key role in releasing the budding particle from the host membrane. Condensates the ribonucleocapsid core during virus assembly. {By SimilarityUniProtKB:P03519}. Inhibits mRNA nuclear export through direct interaction with host RAE1-NUP98 complex, thereby preventing interferon signaling and establishment of antiviral state in infected cells. Induces cell- rounding, cytoskeleton disorganization and apoptosis in infected cell. Inhibits host transcription, possibly through interaction with host DNA repair factor IIH/TFIIH GTF2H5 subunit (By similarity). {By SimilarityUniProtKB:P03519}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory