NucEnvDB
NucEnvDB
A database of Nuclear Envelope Proteins and their Interactions
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Rhophilin-2 - Mus musculus - NucEnvDB
Rhophilin-2 (
Mus musculus
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Cross-References
General Information
Protein Information
Protein Name
Rhophilin-2
Accession Code
Q8BWR8
Gene
Rhpn2
Organism
Mus musculus
| House mouse (Taxonomy:
10090
)
Part of Reference Proteome?
Yes
Sequence (Length: 686)
Show
MTDTLLPAAPQPLEKEGDDYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVREQVRLELSFV
NSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEHYSEDSYLYEDDIADLMDLRQACRT
PSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDSFTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQA
GLESAVDAFQRAAGVLNYLKETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKVCLPGIQNEFFVLVKVAQEAAKVAEA
YRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDRMPEGMTPLATLK
NAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAHQRTQLKHTQHREDDDLLNLIDAPDVLPKTEREV
KITFPDFSKVTVTDFFQKLGPLSVFSASKRWSPPRGIHFTVEEGDLGFTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVS
IQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNKCATYSVGMQKTYSMICLSMDDDDKADKTKKISKKLSF
LSWGTSKNRQKSASTLCLPEVGLARSQNKKKLPTPFSLLNSDSSLY
Structure Viewer (PDB: 1VAE)
Select PDB ID
1VAE
Subcellular Location
Description
Show
Cytoplasm, perinuclear region {
By Similarity
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
Show
Cellular Component
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
Plasma Membrane
(
GO:0005886
)
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Biology & Function
Description
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Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). {
By Similarity
}.
Assigned Ontology terms
Show
Biological Process
Glomerular Filtration
(
GO:0003094
)
Negative Regulation Of Stress Fiber Assembly
(
GO:0051497
)
Signal Transduction
(
GO:0007165
)
Molecular Function
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Cross-References
Database
Links
UNIPROT
Q8BWR8
Q9DBN2
PDB
1VAE
Pfam
PF03097
PF02185
PROSITE
PS51180
PS50106
PS51860
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory