NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein unc-45 homolog B - Mus musculus - NucEnvDB

Protein unc-45 homolog B (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Protein unc-45 homolog B
Accession Code	Q8CGY6
Gene	Unc45b
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 931)
MAEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQLRV QFSTDSRVQTMFEILLNENSEADKREKAANNLIVLGREEAGAERIFQSNGVALLLQLMNTQRPELLLAAVRTLSGMCSGHRARATAILHAVRIDRICSLMALENEEMSLAVCNLLQAIIDSLSGEDKREH RGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLSIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITSKFDPQ DMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVMEMMVALCGSEREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGSDYGLRQFAEGSTEKLAKQCRKWLCN TAIDTRTRRWAVEGLAYLTLDADVKDDFVQDIPALQAMFELAKARTSDKTILYSVANTLVNCTNSYDVKEVVPELVQLAKFSKQHVPEEHPKDKKDFVDLRVKRLLKAGVISALACMVKADSAILTDQTK ELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHGLAKIAAVSNPDIAFPGERVYEVVRPLVSLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKEKALPDIENYMFENHDQLRQA ATECMCNMVLNKEVQERFLADGNDRLKLVVLLCGEDDHKLQNAAAGALAMLTAAHKKLCLKMTEVTTQWLEILQRLCLHDQLSVQHRGLVIAHNLLSADAELARKLVESELLEILTVVGKQEPDEKRAAV VQTARECLIKCMDYGFIKPVS

Subcellular Location

Description
Cytoplasm, myofibril, sarcomere, Z line {By SimilarityUniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band {By SimilarityUniProtKB:Q8IWX7}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000269\|PubMed:18478096}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {By SimilarityUniProtKB:Q6DGE9}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	A Band (GO:0031672) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471) Z Disc (GO:0030018)

Biology & Function

Description
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (PubMed:12356907, PubMed:18326487, PubMed:18478096). Is necessary for normal early lens development (By similarity). {By SimilarityUniProtKB:Q6DGE9, Experimental EvidencePubMed:12356907, Experimental EvidencePubMed:18326487, Experimental EvidencePubMed:18478096}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Chaperone-Mediated Protein Folding (GO:0061077) Lens Development In Camera-Type Eye (GO:0002088) Muscle Organ Development (GO:0007517)
Molecular Function	Hsp90 Protein Binding (GO:0051879)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P97414	Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)	EBI-20564572	0.35
P51637	Caveolin-3 (M-caveolin)	EBI-20565496	0.35

Cross-References

Database	Links
UNIPROT	Q8CGY6 Q5XG72 Q8BHC5 Q8BWK3
Pfam	PF11701
PROSITE	PS50005 PS50293

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