NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Synaptojanin-1 - Mus musculus - NucEnvDB

Synaptojanin-1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Synaptojanin-1
Accession Code	Q8CHC4
Gene	Synj1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1574)
MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRVDASDEDRISEVRKVLNSGNFYF AWSASGVSLDLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQP GLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSILKPQVQKFLDYGFFYFDGSEVQRCQSGTVRTNCLDCLDRT NSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNM CENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVNASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFI RDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTF APTYKYDLFSEDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQKIYKEVIAVQGPPDGTVLVSIKSSAQESTFF DDALIDELLRQFAHFGEVILIRFVEDKMWVTFLEGSSALNALSLNGKELLNRTITITLKSPDWIKHLEEEMSLEKISVTLPSSASSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGT SPSSSPRTSPCQSPTVPEYSAPSLPIRPSRAPSRTPGPPSSQGSPVDTQPAAQKDSSQTLEPKRPPPPRPVAPPARPAPPQRPPPPSGARSPAPARKEFGGVGAPPSPGVARREIEAPKSPGTARKDNIG RNQPSPQAGLAGPGPAGYGAARPTIPARAGVISAPQSQARVCAGRPTPDSQSKPSETLKGPAVLPEPLKPQAAFPQQPSLPTPAQKLQDPLVPIAAPTMPPSGPQPNLETPPQPPPRSRSSQSLPSDSSP QLQQEQPTGQVKINGISGVKQEPTLKSDPFEDLSLSVLAVSKAQPSVQISPVLTPDPKMLIQLPSASQSQVNPLSSVSCMPTRPPGPEESKSQESMGSSANPFPSLPCRNPFTDRTAAPGNPFRVQSQES EATSWLSKEEPVPNSPFPPLMPLSHDTSKASSSLGGFEDNFDLQSQSTVKTSNPKGWVTFDEDDNFPTTGKSKSVCPDLVGNAPASFDDDWSKGASVSFCVLPARRPPPPPPPVPLLPPGTTSSAGPSTT LPSKAPSTLDFTER

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:O18964}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Clathrin Coat (GO:0030118) Clathrin Coat Of Coated Pit (GO:0030132) Cytoplasm (GO:0005737) Glutamatergic Synapse (GO:0098978) Membrane Coat (GO:0030117) Microtubule (GO:0005874) Neuron Projection (GO:0043005) Parallel Fiber To Purkinje Cell Synapse (GO:0098688) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynapse (GO:0098794) Presynapse (GO:0098793) Protein-Containing Complex (GO:0032991) Schaffer Collateral - CA1 Synapse (GO:0098685) Synaptic Membrane (GO:0097060) Terminal Bouton (GO:0043195) Vesicle Membrane (GO:0012506)

Biology & Function

Description
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {By SimilarityUniProtKB:O18964, By SimilarityUniProtKB:O43426}.
Assigned Ontology terms

Biological Process	Brain Development (GO:0007420) Inositol Phosphate Dephosphorylation (GO:0046855) Learning (GO:0007612) Neurotransmitter Transport (GO:0006836) Phosphatidylinositol Dephosphorylation (GO:0046856) Phosphatidylinositol Metabolic Process (GO:0046488) Phosphatidylinositol-Mediated Signaling (GO:0048015) Positive Regulation Of Endosome Organization (GO:1904980) Positive Regulation Of Gliogenesis (GO:0014015) Positive Regulation Of Receptor-Mediated Endocytosis (GO:0048260) Positive Regulation Of Synaptic Vesicle Recycling (GO:1903423) Postsynaptic Neurotransmitter Receptor Internalization (GO:0098884) Regulation Of Postsynaptic Neurotransmitter Receptor Internalization (GO:0099149) Response To Cytokine (GO:0034097) Response To Retinoic Acid (GO:0032526) Synaptic Vesicle Endocytosis (GO:0048488) Synaptic Vesicle Priming (GO:0016082) Synaptic Vesicle Transport (GO:0048489) Synaptic Vesicle Uncoating (GO:0016191)
Molecular Function	EH Domain Binding (GO:1990175) Inositol-1,4,5-Trisphosphate 5-Phosphatase Activity (GO:0052658) Phosphatidylinositol Phosphate 5-Phosphatase Activity (GO:0034595) Phosphatidylinositol-3-Phosphate Phosphatase Activity (GO:0004438) Phosphatidylinositol-4,5-Bisphosphate 5-Phosphatase Activity (GO:0004439) Phosphatidylinositol-4-Phosphate Phosphatase Activity (GO:0043812) Protein C-Terminus Binding (GO:0008022) Protein-Containing Complex Binding (GO:0044877) RNA Binding (GO:0003723) SH3 Domain Binding (GO:0017124)

Protein-Protein Interactions

Interactions with other proteins (8 interactors)

Partner (UniProt)		IntAct	Confidence score
Q96B97	SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)	EBI-6953809	0.52
P63101	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)	EBI-2255635	0.35
P50516	V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha)	EBI-6272793	0.35
F6SEU4	Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)	EBI-16733301	0.53
Q62108	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	EBI-16724752	0.35
Q83BP6	Tetratricopeptide repeat family protein	EBI-21287354	0.37
Q6P1J9	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	EBI-20726660	0.35
Q6NZM9	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-26472902	0.35

Cross-References

Database	Links
UNIPROT	Q8CHC4
Pfam	PF08952 PF03372 PF02383
PROSITE	PS50102 PS50275

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