NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

DCN1-like protein 3 - Homo sapiens - NucEnvDB

DCN1-like protein 3 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	DCN1-like protein 3
Accession Code	Q8IWE4
Gene	DCUN1D3
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 304)
MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESK SNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISR DTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT

Structure Viewer (PDB: 4GBA)

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:19617556, Experimental EvidencePubMed:25349211, Experimental EvidencePubMed:26906416}. Cytoplasm {Experimental EvidencePubMed:18823379, Experimental EvidencePubMed:26906416}. Nucleus {Experimental EvidencePubMed:18823379, Experimental EvidencePubMed:26906416}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:18823379}. Note=After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). {Experimental EvidencePubMed:18823379, Experimental EvidencePubMed:19617556}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Ubiquitin Ligase Complex (GO:0000151)

Biology & Function

Description
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:23201271, PubMed:19617556, PubMed:27542266, PubMed:18823379). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:26906416, PubMed:25349211). {Experimental EvidencePubMed:18823379, Experimental EvidencePubMed:19617556, Experimental EvidencePubMed:23201271, Experimental EvidencePubMed:25349211, Experimental EvidencePubMed:26906416, Experimental EvidencePubMed:27542266}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Cell Growth (GO:0030308) Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle (GO:2000134) Negative Regulation Of Protein Neddylation (GO:2000435) Positive Regulation Of Apoptotic Process (GO:0043065) Positive Regulation Of Protein Neddylation (GO:2000436) Positive Regulation Of Ubiquitin-Protein Transferase Activity (GO:0051443) Protein Neddylation (GO:0045116) Regulation Of Cell Cycle Process (GO:0010564) Regulation Of Protein Neddylation (GO:2000434) Response To Gamma Radiation (GO:0010332) Response To UV-C (GO:0010225)
Molecular Function	Cullin Family Protein Binding (GO:0097602) Ubiquitin Conjugating Enzyme Binding (GO:0031624) Ubiquitin-Like Protein Binding (GO:0032182)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P01112	GTPase HRas, N-terminally processed	EBI-27045317	0.27
Interactions with other proteins (9 interactors)

Partner (UniProt)		IntAct	Confidence score
Q6IQ23	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	EBI-16398399	0.35
Q96Q27	Ankyrin repeat and SOCS box protein 2 (ASB-2)	EBI-21879621	0.35
Q13618	Cullin-3 (CUL-3)	EBI-15794277	0.58
Q13617	Cullin-2 (CUL-2)	EBI-15794136	0.35
Q13616	Cullin-1 (CUL-1)	EBI-15794136	0.35
P61081	NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)	EBI-15794345	0.44
Q16695	Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)	EBI-20937612	0.40
P01116	GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]	EBI-27041844	0.27
P01111	GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)	EBI-27042293	0.27

Cross-References

Database	Links
UNIPROT	Q8IWE4 B3KVY4
PDB	4GBA
Pfam	PF03556
PROSITE	PS51229
OMIM	616167
DisGeNET	123879

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