NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase TRIM68 - Mus musculus - NucEnvDB

E3 ubiquitin-protein ligase TRIM68 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase TRIM68
Accession Code	Q8K243
Gene	Trim68
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 485)
MDPAVLMEAIVEEVNCPICMTFLREPVSISCGHTFCHSCLSGLWKLPGESQNLSYTCPLCRAPVKPRKLRPNWQLASVVDKVRLLGFCMEMGLKTDVCDLHKEQLTMFCKEDDMVTCEACKQSPEHEAHS VVPIKDVAWEYKWKLQQALEHLRKEQEEAWKLEVSEKEQAAIWKTQMERRKQSIRWEFEKYRQLLKEKELPCQQAEEEAAAAQASLEQEKGETASKLELRREAIIRQSQVLWSMIVELEERSQRPVRWML QGIQEALNRSESWTLQQLEPISLELKTDCRVLGLRETLKTFAVDVRLDPDTAYSRLVVSKDRKSVHYGVTQQNLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCVENVDRKEVVYLSPR YGFWVIRLRKGTEYRAGTDEYPLLPLTVPPHRVGIFLDYEAHDISFYNVTDGASHIFTFPCYPFPGRLLPYFSPCYSIDTNNTTPLTICTLGGEG

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q6AZZ1}. Nucleus {By SimilarityUniProtKB:Q6AZZ1}. Note=Colocalized with AR in nucleus. {By SimilarityUniProtKB:Q6AZZ1}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Golgi Apparatus (GO:0005794) Nucleolus (GO:0005730) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. {By SimilarityUniProtKB:Q6AZZ1}.
Assigned Ontology terms

Biological Process	Innate Immune Response (GO:0045087) Positive Regulation Of Autophagy (GO:0010508) Positive Regulation Of I-KappaB Kinase/NF-KappaB Signaling (GO:0043123) Positive Regulation Of NF-KappaB Transcription Factor Activity (GO:0051092) Protein Autoubiquitination (GO:0051865) Protein Polyubiquitination (GO:0000209) Protein Ubiquitination (GO:0016567) Regulation Of Androgen Receptor Signaling Pathway (GO:0060765) Regulation Of Gene Expression (GO:0010468) Regulation Of Protein Localization (GO:0032880) Regulation Of Viral Entry Into Host Cell (GO:0046596)
Molecular Function	Histone Acetyltransferase Binding (GO:0035035) Identical Protein Binding (GO:0042802) Nuclear Androgen Receptor Binding (GO:0050681) Protein Homodimerization Activity (GO:0042803) Protein Kinase Binding (GO:0019901) Ubiquitin Protein Ligase Activity (GO:0061630) Ubiquitin-Protein Transferase Activity (GO:0004842) Zinc Ion Binding (GO:0008270)

Cross-References

Database	Links
UNIPROT	Q8K243
Pfam	PF13765 PF00622 PF00643
PROSITE	PS50188 PS50119 PS00518 PS50089

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