NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Rab effector MyRIP - Mus musculus - NucEnvDB

Rab effector MyRIP (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Rab effector MyRIP
Accession Code	Q8K3I4
Gene	Myrip
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 856)
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKSRFK RFGSAKVLKNLYRKHRLESGACFDILGGGLFEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAESHGDSLDKQNEASYLRDHKQELTEELAGTILQRIIRKQKDKAELRAEEEE PEWPRSQSGSVKARGEGTTAPPGRHKARATFRRSQSAFSFTMEDALKSGSAEAAPRSPKDRAQRLLEEAALPSWRSMDGLDGTNLAPLLQSPDGNWMTLKDGSRQPPTRLLTKPKSGTFQALEVASSVTS AYDEIGSDSEEDFDYSEALSKLCPPSQSRLKQPQPQPTQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLSWLQRKAPKNPAVEKMPLQGELDVNFNPQAAGGETSDSSDPEETLRTAERR ARRWRRARVGPEESNRGLPSPGAHPRALHTAQVSDNVSETDISNETQNSRSSTDSVEEKLRNRLYELAMKMSEKETSSGEDQESESKAEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVI NATEELIAESAGPWEIPPVSTDRENGMFPLGTDQVRLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRD QKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTGDTKDLMEPDLESAVMY

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:12221080}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q7TNY7}. Cytoplasmic vesicle, secretory vesicle {By SimilarityUniProtKB:Q7TNY7}. Melanosome {ECO:0000269\|PubMed:11964381, Experimental EvidencePubMed:12221080}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. In insulin- secreting cells, associated with dense core secretory granules. {ECO:0000269\|PubMed:11964381, Experimental EvidencePubMed:12221080}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Actin Cytoskeleton (GO:0015629) Apical Plasma Membrane (GO:0016324) Cortical Actin Cytoskeleton (GO:0030864) Dense Core Granule (GO:0031045) Exocyst (GO:0000145) Melanosome (GO:0042470) Perinuclear Region Of Cytoplasm (GO:0048471) Photoreceptor Outer Segment (GO:0001750) Secretory Granule Membrane (GO:0030667) Synapse (GO:0045202) Transport Vesicle (GO:0030133)

Biology & Function

Description
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. {Experimental EvidencePubMed:17827149}.
Assigned Ontology terms

Biological Process	Intracellular Protein Transport (GO:0006886) Positive Regulation Of Insulin Secretion (GO:0032024) Vesicle Transport Along Actin Filament (GO:0030050)
Molecular Function	Actin Binding (GO:0003779) Metal Ion Binding (GO:0046872) Myosin Binding (GO:0017022) Protein Kinase A Binding (GO:0051018) Small GTPase Binding (GO:0031267)

Cross-References

Database	Links
UNIPROT	Q8K3I4 A1L320 A1L321 Q8CFC0 Q8K4H5
Pfam	PF02318 PF04698
PROSITE	PS50916

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