NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Spastin homolog - Caenorhabditis elegans - NucEnvDB

Spastin homolog (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Spastin homolog
Accession Code	Q8MNV0
Gene	spas
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 512)
MFAFSKGPAGSSTYDRVAQKFQDGYEKMRAAIEMDELTKHAGSIQEKLRTAELYKEARSLLKEANEFNIMDIPETRRSEIRDKRQNMMKLEKSAQDRLIAICNEVDPNVKQSRSATVGPSRPASAARVTP RPTRATAPEKKNAAKAKENDENRHVCSRGDRCGAHHQPVTKKSDTVHPEPPVQASNRKMETVKRVKVDKASLPMHQNPVNRAALLNGVDKVIGERLLDEVLDNTGVRMDDVAGCHSAKAALEEAVILPAL NPNLFKGLRQPVKGILLFGPPGNGKTLLAKAVAGESKQMFFNISASSLTSKWVGDSEKTIRGLFQIARNAQPSIIFIDEIDSILCERSEKDAEVSRRMKTEFLVQFDGATSSADDRILVIGATNRPHELD DAVLRRFPKRIMLNLPDEEARKELITKTLKKHNMMDGLISSDIRYIASNTSGFSNSDLVALCKEAAMVPIREIDRSKLSMTDGEKIRKIRASDFDTALRTIRPSTSQKIMSKLSDFSRSFGC

Subcellular Location

Description
Membrane {Sequence Analysis}; Peripheral membrane protein {By SimilarityUniProtKB:Q9UBP0}. Cytoplasm, cytoskeleton {Experimental EvidencePubMed:17531954}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:17531954}. Note=Forms an intramembrane hairpin-like structure in the membrane (By similarity). Localizes to the cytoskeleton, perinuclear region and cytoplasm in early embryos (PubMed:17531954). {By SimilarityUniProtKB:Q9UBP0, Experimental EvidencePubMed:17531954}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q9UBP0}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Membrane (GO:0016020) Microtubule (GO:0005874) Microtubule Cytoskeleton (GO:0015630) Perinuclear Region Of Cytoplasm (GO:0048471) Protein-Containing Complex (GO:0032991)

Biology & Function

Description
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules (PubMed:17531954, PubMed:19619244, PubMed:22561316, PubMed:18202664). Probably by regulating microtubule remodeling, plays a role in new synapse formation in GABAergic DD (Dorsal D type) neurons (PubMed:26051896). {Experimental EvidencePubMed:17531954, Experimental EvidencePubMed:18202664, Experimental EvidencePubMed:19619244, Experimental EvidencePubMed:22561316, Experimental EvidencePubMed:26051896}.
Assigned Ontology terms

Biological Process	Microtubule Bundle Formation (GO:0001578) Microtubule Depolymerization (GO:0007019) Microtubule Severing (GO:0051013) Nervous System Development (GO:0007399) Nucleus Localization (GO:0051647) Oogenesis (GO:0048477) Positive Regulation Of Microtubule Depolymerization (GO:0031117) Vulval Development (GO:0040025)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Identical Protein Binding (GO:0042802) Isomerase Activity (GO:0016853) Microtubule Binding (GO:0008017) Microtubule Severing ATPase Activity (GO:0008568)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q8MNV0	Self	EBI-15680282	0.62

Cross-References

Database	Links
UNIPROT	Q8MNV0 G5EEF8 Q7M3K5 Q8MNU9
Pfam	PF00004 PF17862
PROSITE	PS00674

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