NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ankyrin repeat and LEM domain-containing protein 2 homolog - Drosophila melanogaster - NucEnvDB

Ankyrin repeat and LEM domain-containing protein 2 homolog (Drosophila melanogaster)

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Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Ankyrin repeat and LEM domain-containing protein 2 homolog
Accession Code	Q8MQX9
Gene	Ankle2
Organism	Drosophila melanogaster (Taxonomy: 7227)
Part of Reference Proteome?	Yes
Sequence (Length: 1174)
MSTYFGVYIPTSKAGCFEGSVSQCIGSIAAVNIKPSNPASGSASVASGSPSGSAASVQTGNADDGSAATKYEDPDYPPDSPLWLIFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKRF CKAKPESKPIPIISGSGYKSSPTSTDNSCSSSPTGNGSGFIIPLGSNSSMSNLLLSDSPTSSPSSSSNVIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQELVEFRKQIEGGHIDRVKRIIWENPR FLISSGDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAALNISLLDYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYPECKSLRNHEGKEPKEIICLRNANATHVT IKKLELLLYDPHFVPVLRSQSNTLPPKVGQPFSPKDPPNLQHKADDYEGLSVDLAISALAGPMSREKAMNFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRVLFSPLAE ATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYRNNNSFDSPSLADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLDSFLDIGTTEG LARLEAYFLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRKDKNEAAGATSPSAGVMTPYTCVEKSLQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSFKDDARFISVDFSKVHSRIAH LVASYVTHSQEVSVAMRLQLLQMLRSLRQLLADERGREQHLGCVCASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRTKSLRAAAVVQSQGQLQDTSGSTGSSALHAS LGVGSTSLGASRVVASASKDAWRRQQSDDEDYDSDEQVIFFDCTNVTLPYGSSSEDEENFRTPPQSLSPGISMDLEPRYELFIFGNEPTKRDLDVLNALSNVDIDKETLPHVYAWKTAMESYSCAEMNLF PSPRNVKVQKPEPWYSGTSSSHNSQPLLHPKRLLATPKLNAVVSGRRGSGPLTAPVTPRLARTPSAASIQVASETNGESVGTAVTPASPILSFAALTAATQSFQTPLNKVRGLFSQYRDQRSYNEGDTPL GNRN

Subcellular Location

Description
Endoplasmic reticulum {Experimental EvidencePubMed:31735666}. Nucleus envelope {Experimental EvidencePubMed:31735666}. Cytoplasm {Experimental EvidencePubMed:31735666}. Note=In neuroblasts, recruited to the nuclear envelope at the initiation of mitosis and remains associated with it until the beginning of cytokinesis. {Experimental EvidencePubMed:31735666}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endomembrane System (GO:0012505) Endoplasmic Reticulum (GO:0005783) Nuclear Envelope (GO:0005635)

Biology & Function

Description
Involved in brain development probably by regulating asymmetric division of neuroblasts (PubMed:31735666, PubMed:30550790, PubMed:25259927). Regulates neuroblast asymmetric cell division by controlling asymmetric protein localization of Mira, Baz, Par-6 and aPKC, and spindle alignment (PubMed:31735666). Also, regulates the localization of kinase Ball during mitosis, specifically maintaining Ball in the nucleus during interphase (PubMed:31735666). Required for proper ER and nuclear envelope morphology in neuroblasts (PubMed:31735666). {Experimental EvidencePubMed:25259927, Experimental EvidencePubMed:30550790, Experimental EvidencePubMed:31735666}.
Assigned Ontology terms

Biological Process	Asymmetric Neuroblast Division (GO:0055059) Asymmetric Protein Localization Involved In Cell Fate Determination (GO:0045167) Cell Morphogenesis (GO:0000902) Endoplasmic Reticulum Organization (GO:0007029) Negative Regulation Of Phosphorylation (GO:0042326) Nuclear Membrane Reassembly (GO:0031468) Positive Regulation Of Protein Dephosphorylation (GO:0035307) Spindle Localization (GO:0051653)
Molecular Function	Protein Phosphatase 2A Binding (GO:0051721)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9VXY7	Lipid storage droplets surface-binding protein 2 (Lsd2)	EBI-9936142	0.35

Cross-References

Database	Links
UNIPROT	Q8MQX9 Q0KHR1 Q9VX44 X2JCC5
Pfam	PF13637
PROSITE	PS50297 PS50088

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