NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase RNF128 - Homo sapiens - NucEnvDB

E3 ubiquitin-protein ligase RNF128 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase RNF128
Accession Code	Q8TEB7
Gene	RNF128
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 428)
MGPPPGAGVSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPV AGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSH PGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQ SRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCD ILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAV DVIPHVDNPTFEEDETPNQETAVREIKS

Structure Viewer (PDB: 3ICU)

Subcellular Location

Description
Endomembrane system {By Similarity}; Single-pass membrane protein {By Similarity}. Cytoplasm, cytoskeleton {Experimental EvidencePubMed:12705856, ECO:0000269\|PubMed:22016387}. Cytoplasm, perinuclear region {By Similarity}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Golgi Apparatus (GO:0005794) Late Endosome (GO:0005770) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. {Experimental EvidencePubMed:12705856, Experimental EvidencePubMed:22016387}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Cytokine Production (GO:0001818) Positive Regulation Of Protein Catabolic Process In The Vacuole (GO:1904352) Protein Localization To Lysosome (GO:0061462) Regulation Of Protein Stability (GO:0031647) Ubiquitin-Dependent Protein Catabolic Process (GO:0006511)
Molecular Function	Metal Ion Binding (GO:0046872) Ubiquitin Protein Ligase Activity (GO:0061630)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P63279	SUMO-conjugating enzyme UBC9	EBI-2341627	0.37
P0C6X7	2'-O-methyltransferase nsp16	EBI-25488783	0.37
Interactions with other proteins (5 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9NPD8	Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)	EBI-2341840	0.37
Q92624	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)	EBI-10275130	0.56
Q8TAP6	Centrosomal protein of 76 kDa (Cep76)	EBI-10275120	0.72
Q9UHD9	Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)	EBI-24442817	0.56
Q15036	Sorting nexin-17	EBI-24588332	0.56

Cross-References

Database	Links
UNIPROT	Q8TEB7 A0PJI4 Q6PH80 Q6ZTJ8 Q96RF3 Q9H5E4
PDB	3ICU
Pfam	PF02225 PF13639
PROSITE	PS50089
OMIM	300439
DisGeNET	79589

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