NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ribonuclease TUDOR 1 - Arabidopsis thaliana - NucEnvDB

Ribonuclease TUDOR 1 (Arabidopsis thaliana)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Ribonuclease TUDOR 1
Accession Code	Q8VZG7
Gene	TSN1
Organism	Arabidopsis thaliana \| Thale cress (Taxonomy: 3702)
Part of Reference Proteome?	Yes
Sequence (Length: 991)
MATGAENQWLKGRVKAVTSGDCLVITALSHNRAGPPPEKTITFSSLMAPKMARRGGIDEPFAWESKEFLRKLCIGKEVAFKVDYKVEAIAGREFGSVFLGNENLAKLVVKTGWAKVREPGQQNQDKVSPY IKELLQLEELAKQEGYGRWSKVPGAAEASIRNLPPSAIGDSAGFDAMGLLAANKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGVQAPSMGRRTTNGSVVETVPDEPNGDVSAESRGPLTTAQRLA ASAASSVEVSSDPFATEAKYFTEHRVLSRDVRIVLEGVDKFNNLIGSVHYSDGETVKDLGLELVENGLAKFVEWSANMMEEEAKKKLKAAELQCKKDKVKMWANYVPPATNSKAIHDQNFTGKVVEVVSG DCLIVADDAVPFGSPAAERRVCLSSIRSPKMGNPRREEKPAPYAREAREFLRQRLIGKQVIVQMEYSRKVTQGDGPTTSGAADRFMDFGSVFLPSAAKADSDEVTAPPAAAIAGSQPVGVNIAELVLVRG FGNVVRHRDFEERSNHYDALLAAEARALAGKKGIHSAKESPAMHITDLTVSAAKKAKDFLPSLQRIRRIPAVVEYVLSGHRFKLYIPKITCSIAFSFSGVRCPGRGEPYSEEAISVMRRRIMQRDVEIEV ETVDRTGTFLGSMWESRTNVATVLLEAGLAKMQTSFGADRIAEAHLLEQAERSAKNQKLKIWENYVEGEEVSNGNTNTVETRQKETLKVVVTEVLGGGRFYVQSAGDQKIASIQNQLASLSIKDAPIIGS FNPKRGDIVLAQFSLDNSWNRAMIVTAPRAAVQSPDEKFEVFYIDYGNQETVPYSAIRPIDPSVSAAPGLAQLCRLAYIKVPSLEDDFGPEAGEYLHTVTLGSGKEFKAVIEERDTSGGKVKGQGTGTEF VVTLIAVDDEISVNAAMLQEGIARMEKRQKWGHKGKQAALDALEKFQEEARKSRIGIWQYGDIESDDEDTGPARKPAGGRR

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:20484005, Experimental EvidencePubMed:25205572, Experimental EvidencePubMed:25736060}. Cytoplasmic granule {Experimental EvidencePubMed:25205572, Experimental EvidencePubMed:25736060}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:20484005}. Endoplasmic reticulum {Experimental EvidencePubMed:20484005}. Note=Accumulates heterogeneously in the cytosol, in patches around the nucleus and in the cell periphery, and relocates transiently to a diffuse pattern in response to salt stress (PubMed:20484005). Accumulates in cytoplasmic stress granules (SGs) and processing bodies (PBs) in response to abiotic stresses (e.g. salt and heat) (PubMed:25205572, PubMed:25736060). {Experimental EvidencePubMed:20484005, Experimental EvidencePubMed:25205572, Experimental EvidencePubMed:25736060}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoplasmic Stress Granule (GO:0010494) Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Nuclear Envelope (GO:0005635) Nucleus (GO:0005634) P-Body (GO:0000932) Perinuclear Region Of Cytoplasm (GO:0048471) Plant-Type Cell Wall (GO:0009505) Plasma Membrane (GO:0005886) RISC Complex (GO:0016442)

Biology & Function

Description
Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress (PubMed:25736060). Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat) (PubMed:25736060). Involved in gibberellic acid (GA) biosynthesis (PubMed:25205572). Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway (PubMed:20484005). Component of stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20OX3 mRNA. Binds GA20OX3 mRNA (PubMed:25205572). May inhibit the degradation of mRNAs involved in stress adaptation (PubMed:26237081). {Experimental EvidencePubMed:20484005, Experimental EvidencePubMed:25205572, Experimental EvidencePubMed:25736060, Experimental EvidencePubMed:26237081}.
Assigned Ontology terms

Biological Process	Cellular Response To Heat (GO:0034605) RNA-Mediated Gene Silencing (GO:0031047) MRNA Catabolic Process (GO:0006402) MRNA Processing (GO:0006397) Positive Regulation Of Gibberellin Biosynthetic Process (GO:0010372) Response To Salt Stress (GO:0009651)
Molecular Function	MRNA Binding (GO:0003729) Nuclease Activity (GO:0004518) RNA Binding (GO:0003723)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9LV27	Target of rapamycin complex subunit LST8-1 (TORC subunit LST8 homolog 1) (Lethal with SEC13 protein 8 homolog 1)	EBI-21137684	0.35

Cross-References

Database	Links
UNIPROT	Q8VZG7 F4K6N0 Q9LY25
Pfam	PF00565 PF00567
PROSITE	PS50830 PS50304

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