NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Nanos homolog 1 - Homo sapiens - NucEnvDB

Nanos homolog 1 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Nanos homolog 1
Accession Code	Q8WY41
Gene	NANOS1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 292)
MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGNGGGGSPPSSS SSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRGRYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAA VLLGCAPAAAAAATTTSEATPREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVL CPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR

Structure Viewer (PDB: 4CQO)

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:12690449, Experimental EvidencePubMed:17047063, Experimental EvidencePubMed:19168546}. Cytoplasm {Experimental EvidencePubMed:12690449, Experimental EvidencePubMed:17047063, Experimental EvidencePubMed:19168546}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {Experimental EvidencePubMed:12690449, Experimental EvidencePubMed:19168546}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {Experimental EvidencePubMed:17047063, Experimental EvidencePubMed:18223680}.
Assigned Ontology terms

Biological Process	Cell Migration (GO:0016477) Cerebellar Neuron Development (GO:0098749) Epithelial Cell Migration (GO:0010631) Negative Regulation Of Translation (GO:0017148) Oogenesis (GO:0048477) Positive Regulation Of Nuclear-Transcribed MRNA Catabolic Process, Deadenylation-Dependent Decay (GO:1900153) Post-Transcriptional Regulation Of Gene Expression (GO:0010608) Regulation Of Cell Growth (GO:0001558) Tissue Homeostasis (GO:0001894)
Molecular Function	MRNA Binding (GO:0003729) Translation Repressor Activity (GO:0030371) Zinc Ion Binding (GO:0008270)

Disease associations

Description
Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno- teratozoospermia are features observed in SPGF12 patients. {Experimental EvidencePubMed:23315541}. Note=The disease is caused by variants affecting the gene represented in this entry.
Database Associations
OMIM	608226 615413
DisGeNET	340719

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
O60716	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	EBI-9639078	0.52

Cross-References

Database	Links
UNIPROT	Q8WY41
PDB	4CQO
Pfam	PF05741
PROSITE	PS51522
OMIM	608226 615413
DisGeNET	340719

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