NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cytoplasmic FMR1-interacting protein 1 homolog - Danio rerio - NucEnvDB

Cytoplasmic FMR1-interacting protein 1 homolog (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Cytoplasmic FMR1-interacting protein 1 homolog
Accession Code	Q90YM8
Gene	cyfip1
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 1253)
MASTVTLEDALSNVDLLEELPLPDQQPCIEPLPSSLIYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNDMLEEGQQYAVMLYTWRCCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVNKLMNFMYFQR TAIDRFCGEVRRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMSEPSSIQESQNLSMFLANHNKITQSLQQQLEVINGYDELLADIVNLCVDYYENKMYLTPSER HMLLKVMGFGLYLMDGSNSNIYKLEAKKRINLTKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWSCTSTGSSPQYNVCEQMIQIREGHMRFISELARYSNSEVVTGSGRQDAQKTDSEYRKL FDLALQGLQLLSQWSAQIMEVYSWKLVHPTDKYSNKECPDNAEEYERATRYNYTSEEKFALVEVLAMIKGLQVLMGRMESVFNHAIRHTIYSALQDFAQVTLREPLRQAIKKKKNVVQSVLQAIRKTVCD WETGREPHNDPALRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLVADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLLNFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTD HILETKEASMMEYVLYSLDLYNDSAHYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVIAGSLLLDKRLRAECKNQGANISWPSSNRYETLLKQRHVQLLGRSIDLNRLITQRVSSALYKSL ELAISRFESEDLTSIMELEGLLDINRMTHKLLSKYLTLDSIDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTILPFSQEFQRDKPPNAQPQYLYGSKALNLAYSSIYSLYRNFVG PPHIKAICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKSVCFQNLREVGNALLFCLLTEQSLSQEEVCDLLHAAPFQNILPRVHVKEG ERLDAKMKRLEAKYTALHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSIFEVILTRVRAYLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGAHEFTVEQCFGDGLNWAGCMIITLLGQ HRRFDILDFSYHLLKVQKHDGKDEIIKSVPLKKMVDRIRKFQILNDEIFAILNKYLKSGDGENMPVEHVRCFQPPIHQSLASN

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q7TMB8}. Cell projection, lamellipodium {By SimilarityUniProtKB:Q7TMB8}. Cell projection, ruffle {By SimilarityUniProtKB:Q7TMB8}. Synapse, synaptosome {By SimilarityUniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {By SimilarityUniProtKB:Q7TMB8}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cytoplasm (GO:0005737) Lamellipodium (GO:0030027) Neuron Projection (GO:0043005) Perinuclear Region Of Cytoplasm (GO:0048471) Ruffle (GO:0001726) SCAR Complex (GO:0031209) Synapse (GO:0045202)

Biology & Function

Description
Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity). {By SimilarityUniProtKB:Q7L576, By SimilarityUniProtKB:Q7TMB8}.
Assigned Ontology terms

Biological Process	Axon Extension (GO:0048675) Axon Guidance (GO:0007411) Cell Morphogenesis (GO:0000902) Cell Projection Assembly (GO:0030031) Lamellipodium Assembly (GO:0030032) Modification Of Synaptic Structure (GO:0099563) Regulation Of Actin Filament Polymerization (GO:0030833) Regulation Of Cell Shape (GO:0008360) Regulation Of Translation (GO:0006417) Ruffle Organization (GO:0031529)
Molecular Function	Actin Filament Binding (GO:0051015) RNA 7-Methylguanosine Cap Binding (GO:0000340) Small GTPase Binding (GO:0031267)

Cross-References

Database	Links
UNIPROT	Q90YM8 Q58ES3
Pfam	PF07159 PF05994

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