NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Optineurin - Gallus gallus - NucEnvDB

Optineurin (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Optineurin
Accession Code	Q90Z16
Gene	OPTN
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 556)
MSSKPQIRPAENGEHCRSKMENGMDSMAPPTLSTYTPEEMVQQMKELITENNELKEAMKLHNQAMKDRYEELSIWREKQKEEREFYETKFKEAKQCLLAKCVENEQLQQQLQSLKEREEGAEMEGCATPE KEARQLKSKVQRLQAEKADLLAIISELQVKLNIASAEDSFVEIGMNEEVNRTARENQDNSSEMASNIAVYIRSKSADESKNLESEELTVSQLLCCLRNETQRREKLEKELQDHKERLSKMENETSNCLES GTQTNQEEESSEAIGSEVESLKKQICALFKELQEAHEKLKEAELIQKKLQEKCQTLEKVNSAAATELEEKQQLIYTIKKLELQVESVQAEVKLEQAKTQDEKTRYSSLQDAYNKLLAELTEAMKTISEMK VKEHDRVDKVVVEELNAKVLLAEQALAAKQLQMDEMKQLIAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLAVQLAYLLKEQQNLEDLGRSSLAEMQNRHGARAPDREHSPRLVQRGTGS QEWPEQRNISIYSCPKCEEILPDLDTLQIHVMDCIN

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:11777338, Experimental EvidencePubMed:12169269}. Cytoplasm, perinuclear region {By Similarity}. Golgi apparatus {Experimental EvidencePubMed:12169269}. Golgi apparatus, trans-Golgi network {By Similarity}. Cytoplasmic vesicle {By Similarity}. Recycling endosome {By Similarity}. Cytoplasmic vesicle, autophagosome {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Autophagosome (GO:0005776) Cytoplasm (GO:0005737) Golgi Apparatus (GO:0005794) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Recycling Endosome (GO:0055037)

Biology & Function

Description
Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. {Experimental EvidencePubMed:11777338, Experimental EvidencePubMed:12169269}.
Assigned Ontology terms

Biological Process	Autophagy (GO:0006914) Golgi Ribbon Formation (GO:0090161) Protein Localization To Golgi Apparatus (GO:0034067) Regulation Of I-KappaB Kinase/NF-KappaB Signaling (GO:0043122) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	K63-Linked Polyubiquitin Modification-Dependent Protein Binding (GO:0070530) Metal Ion Binding (GO:0046872)

Cross-References

Database	Links
UNIPROT	Q90Z16
Pfam	PF16516 PF11577
PROSITE	PS51801

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