NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ufm1-specific protease - Caenorhabditis elegans - NucEnvDB

Ufm1-specific protease (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Ufm1-specific protease
Accession Code	Q94218
Gene	odr
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 589)
MTNSQTVSLIGPTQMAPQSTPPPPVNELWFIDAQAMFQNYANLRSFSKSNANEINTTIGGFVFGRKARKQVIHVLFAYAE DLTESNRQFLESSLSADIELVGNLNIDGQSQILPGGQFTLQLTSRMLENRSISEFLDMNVMFNNEHVLMEGASCVSRVGY EWSLRAGREQEDVKSAAERLSMASFRFTYLNAEHGLVIREQKPEAAQQKYLDKFSKGAVPYKDVIEFTAMQSLTRDTSND TEDQKLVPTVKVTKDNKHFTRLVTIGEVVFPAFFGDSSLDLYKRSREAFNRRANNTMMVTVNGIRAGRGVTTTTSATYLP PGWVSLLHLQLPTKWTDNEQRNYRIRLHKLFNLPSSKPVLRLSQALALHSESARLTNKKLIREPHLSITNYQPVGEITTV NGPYNYHHYMQDGIDDSGWGCAYRSFQTIWSWFILNGYTDKPVPSHREIQQALVDIQDKQAKFVGSRQWIGSTEISFVLN ELLKLECRFIATNSGAEVVERVRELARHFETSGTPVMIGGNMLAHTILGVDFNDTTGETKFLVLDPHYTGSEDIKTITSK GWCAWKPASFWSKDHFYNMVLPQPPSDAI

Structure Viewer (PDB: 5EJJ)

Subcellular Location

Description
Endoplasmic reticulum membrane {Experimental EvidencePubMed:23449979, Experimental EvidencePubMed:24603482}; Peripheral membrane protein {Experimental EvidencePubMed:24603482}. Cytoplasm {Experimental EvidencePubMed:24603482}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:23449979}. Note=Recruited to the endoplasmic reticulum upon interaction with odr-4. {Experimental EvidencePubMed:24603482}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Experimental Evidence {ECO:0000269\|PubMed:24603482}
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum Membrane (GO:0005789) Perinuclear Region Of Cytoplasm (GO:0048471) Protein-Containing Complex (GO:0032991)

Biology & Function

Description
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:29251776, PubMed:24603482). Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC (PubMed:9590179). Operates in aggregation behavior, and responses to oxygen levels (PubMed:12410303). {Experimental EvidencePubMed:12410303, Experimental EvidencePubMed:24603482, Experimental EvidencePubMed:29251776, Experimental EvidencePubMed:9590179}.
Assigned Ontology terms

Biological Process	Chemotaxis (GO:0006935) Positive Regulation Of Chemotaxis (GO:0050921) Protein Localization To Non-Motile Cilium (GO:0097499) Proteolysis (GO:0006508) Response To Ethanol (GO:0045471)
Molecular Function	DeUFMylase Activity (GO:0071567)

Cross-References

Database	Links
UNIPROT	Q94218 Q86MF8
PDB	5EJJ 5XDA
Pfam	PF07910

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