NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Diacylglycerol O-acyltransferase 2 - Homo sapiens - NucEnvDB

Diacylglycerol O-acyltransferase 2 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Diacylglycerol O-acyltransferase 2
Accession Code	Q96PD7
Gene	DGAT2
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 388)
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNW AVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRK GFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN

Subcellular Location

Description
Endoplasmic reticulum membrane {Experimental EvidencePubMed:14521909, Experimental EvidencePubMed:27184406}; Multi-pass membrane protein {Experimental EvidencePubMed:14521909}. Lipid droplet {Experimental EvidencePubMed:27184406}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:27184406}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Obsolete Integral Component Of Endoplasmic Reticulum Membrane (GO:0030176) Intracellular Membrane-Bounded Organelle (GO:0043231) Lipid Droplet (GO:0005811) Mitochondrion (GO:0005739) Perinuclear Endoplasmic Reticulum Membrane (GO:1990578) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1- monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {By SimilarityUniProtKB:Q9DCV3, Experimental EvidencePubMed:27184406, Experimental EvidencePubMed:28420705}.
Assigned Ontology terms

Biological Process	Bile Acid Signaling Pathway (GO:0038183) Cellular Response To Oleic Acid (GO:0071400) Cellular Triglyceride Homeostasis (GO:0035356) Cholesterol Homeostasis (GO:0042632) Diacylglycerol Biosynthetic Process (GO:0006651) Diacylglycerol Metabolic Process (GO:0046339) Fat Pad Development (GO:0060613) Fatty Acid Homeostasis (GO:0055089) Glycerol Metabolic Process (GO:0006071) Lipid Metabolic Process (GO:0006629) Lipid Storage (GO:0019915) Long-Chain Fatty-Acyl-CoA Metabolic Process (GO:0035336) Low-Density Lipoprotein Particle Clearance (GO:0034383) Monoacylglycerol Biosynthetic Process (GO:0006640) Negative Regulation Of Fatty Acid Oxidation (GO:0046322) Positive Regulation Of Gluconeogenesis (GO:0045722) Positive Regulation Of Triglyceride Biosynthetic Process (GO:0010867) Regulation Of Cholesterol Metabolic Process (GO:0090181) Regulation Of Lipoprotein Metabolic Process (GO:0050746) Regulation Of Plasma Lipoprotein Particle Levels (GO:0097006) Triglyceride Biosynthetic Process (GO:0019432)
Molecular Function	2-Acylglycerol O-Acyltransferase Activity (GO:0003846) Diacylglycerol O-Acyltransferase Activity (GO:0004144) Protein Homodimerization Activity (GO:0042803) Retinol O-Fatty-Acyltransferase Activity (GO:0050252)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P55072	Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)	EBI-9519939	0.40
Q9UKV5	E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)	EBI-9520083	0.40

Cross-References

Database	Links
UNIPROT	Q96PD7 A6ND76 Q5U810 Q68CL3 Q68DJ0 Q8NDB7 Q96BS0 Q9BYE5
Pfam	PF03982
OMIM	606983
DisGeNET	84649

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