NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Gasdermin-A, C-terminal - Homo sapiens - NucEnvDB

Gasdermin-A, C-terminal (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Gasdermin-A, C-terminal
Accession Code	Q96QA5
Gene	GSDMA
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 445)
MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQE RKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTL KEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLS SLGDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS

Subcellular Location

Description
[Gasdermin-A]: Cytoplasm, perinuclear region {Experimental EvidencePubMed:17471240}. Cytoplasm, cytosol {By SimilarityUniProtKB:Q5Y4Y6}. [Gasdermin-A, N-terminal]: Cell membrane {By SimilarityUniProtKB:Q5Y4Y6}; Multi-pass membrane protein {By SimilarityUniProtKB:Q5Y4Y6}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q5Y4Y6}
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
[Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death. {Experimental EvidencePubMed:27281216}. [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216). Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216). Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:27281216). The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216). {Experimental EvidencePubMed:17471240, Experimental EvidencePubMed:27281216}.
Assigned Ontology terms

Biological Process	Apoptotic Process (GO:0006915) Defense Response To Bacterium (GO:0042742) Pyroptosis (GO:0070269)
Molecular Function	Phosphatidylinositol-4,5-Bisphosphate Binding (GO:0005546) Phosphatidylinositol-4-Phosphate Binding (GO:0070273) Phosphatidylserine Binding (GO:0001786)

Protein-Protein Interactions

Interactions with other proteins (12 interactors)

Partner (UniProt)		IntAct	Confidence score
O75593	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2)	EBI-11320921	0.35
P02654	Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]	EBI-23875424	0.56
P55056	Apolipoprotein C-IV (Apo-CIV) (ApoC-IV) (Apolipoprotein C4)	EBI-25158560	0.56
O43309	Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96)	EBI-21572679	0.35
Q9NU19	TBC1 domain family member 22B	EBI-21575852	0.35
Q9UMR2	ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B)	EBI-21616596	0.35
Q15915	Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1)	EBI-21696712	0.35
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-21360986	0.35
Q9P2S5	WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)	EBI-25486895	0.35
P69479	Phosphoprotein (Protein P) (Protein M1)	EBI-25568044	0.35
O43781	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK)	EBI-28931148	0.35
Q14296	Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8)	EBI-28941126	0.35

Cross-References

Database	Links
UNIPROT	Q96QA5 Q32MC5 Q86VE7 Q8N1M6
Pfam	PF04598 PF17708
OMIM	611218
DisGeNET	284110

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