National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | UDP-glucuronosyltransferase 2B28 |
| Accession Code | Q9BY64 |
| Gene | UGT2B28 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 529) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766). Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766). {Experimental EvidencePubMed:11300766}. [Isoform 2]: Lack UDP-glucuronosyltransferase (UGT) activity. {Experimental EvidencePubMed:11300766}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q9BY64 B5BUM0 Q9BY62 Q9BY63 |
| Pfam | PF00201 |
| PROSITE | PS00375 |
| OMIM | 606497 |
| DisGeNET | 54490 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory