NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Septin-14 - Mus musculus - NucEnvDB

Septin-14 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Septin-14
Accession Code	Q9DA97
Gene	Septin14
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 430)
MAEKPTNTSVPIPGSEDPQKENIRCLSTLGHFGFECLPTQLVNKSIQKGFSFNILCVGETGIGKTTLINTLFNTNLKETKSSHFYSKVGLTVKTYELLERNIPLRLTVVKTVGYGDQINKEASYQPVVDY LDAQFEAYLQEELKIKRSLADYHDSRIHVCLYFITPTGHSLKSLDLLTMKSIDRRVNIIPLIAKADSLSKNDLQRFKNNIMSELNSNGIQIYQFQVDDEASAQVNSSGLLPFAVVGSMEEVKVGKRMVRG RHYPWGVLQEVENENHCDFVKLRDLLLSTNMEDLKDQTHTQHYECYRSNRLQKLGFSDTGPDNRPVSFQEMYEAKRREFHNQCQKEEEELKQTFMQRVKEKELTFKDAEKELQDKFEHLKRIQQEEILKL EEERRKLEEQIIDFYKMKAASESAQAQVCTNIKKDKDRKK

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:20181826}. Cytoplasm, cytoskeleton {Experimental EvidencePubMed:33228246}. Cell projection, axon {Experimental EvidencePubMed:20181826}. Cell projection, dendrite {Experimental EvidencePubMed:20181826}. Perikaryon {Experimental EvidencePubMed:20181826}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:33228246}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250\|UniProtKB:Q6ZU15}. Note=Colocalizes with actin stress fibers (By similarity). Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (PubMed:33228246). {ECO:0000250\|UniProtKB:Q6ZU15, Experimental EvidencePubMed:33228246}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Acrosomal Vesicle (GO:0001669) Axon (GO:0030424) Cell Division Site (GO:0032153) Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Dendrite (GO:0030425) Microtubule Cytoskeleton (GO:0015630) Perikaryon (GO:0043204) Perinuclear Region Of Cytoplasm (GO:0048471) Septin Complex (GO:0031105) Septin Ring (GO:0005940)

Biology & Function

Description
Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (PubMed:20181826). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (By similarity). {By SimilarityUniProtKB:Q6ZU15, Experimental EvidencePubMed:20181826, Curator Inference}.
Assigned Ontology terms

Biological Process	Cytoskeleton-Dependent Cytokinesis (GO:0061640) Neuron Migration (GO:0001764) Protein Localization (GO:0008104) Protein Localization To Perinuclear Region Of Cytoplasm (GO:1905719) Spermatid Development (GO:0007286)
Molecular Function	GTP Binding (GO:0005525) GTPase Activity (GO:0003924) Molecular Adaptor Activity (GO:0060090)

Cross-References

Database	Links
UNIPROT	Q9DA97 E9QMM2
Pfam	PF00735
PROSITE	PS51719

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