NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Syncoilin - Mus musculus - NucEnvDB

Syncoilin (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Syncoilin
Accession Code	Q9EPM5
Gene	Sync
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 470)
MASPEPLRGGDGARASREPHTEASFPLQESESPKEAKTFNPEATLSLEGTVNLEDILYLGASGDFEESFYEEEYEKPALTLFIDESRQPDEALGLEEPVRPEEMLSVEESVTPDEVQISEQPVEPAKSPT ACEGEMVATEGSLPAQPIPNTEEDPLSVEDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTKECVAYQYQLECRQQDVAQFA DCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQ KRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLEQADAPTSQAGGVEAQSPGTV

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:11053421, Experimental EvidencePubMed:11694502, Experimental EvidencePubMed:17629480}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern. {Experimental EvidencePubMed:11053421, Experimental EvidencePubMed:11694502, Experimental EvidencePubMed:17629480}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Intermediate Filament (GO:0005882) Neuromuscular Junction (GO:0031594) Perinuclear Region Of Cytoplasm (GO:0048471) Sarcolemma (GO:0042383) Z Disc (GO:0030018)

Biology & Function

Description
Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. {Experimental EvidencePubMed:11694502, Experimental EvidencePubMed:18367591}.
Assigned Ontology terms

Biological Process	Intermediate Filament-Based Process (GO:0045103)
Molecular Function

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Y4J8	Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)	EBI-7424047	0.54
P31001	Desmin	EBI-8031285	0.46
P15331	Peripherin	EBI-27023883	0.46

Cross-References

Database	Links
UNIPROT	Q9EPM5 Q3KP79 Q3TKN1 Q3TUH9 Q8C4J4 Q9CT88
Pfam	PF00038
PROSITE	PS51842

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