NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ubiquitin carboxyl-terminal hydrolase 29 - Mus musculus - NucEnvDB

Ubiquitin carboxyl-terminal hydrolase 29 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Ubiquitin carboxyl-terminal hydrolase 29
Accession Code	Q9ES63
Gene	Usp29
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 869)
MAHLKINGLVQIRSTNRSKHTRASQWKEAVIEIVERKQKVNLVVSFKLEERRRVFQLGDNVTGVVVSGELGLYHLDLTLRDDTSLLIDKLSSADVEHLKSFLDSSTPCESQQPMEPMSSQDDLESSDPFC GEHQEAACGSLNTTPESGTPLSRKMPLSMSNTTGGQKRGEKQGRKRKTEPSSSSAEVNKDIPKENTPDQKKKSRRYYSRNRGGKAEKAVTLREQEKRSNWKLEPAFNSKSYGRANLDGTILPIATCSDDR DVSIFGLEIITHNGVQSLPDPYLNQLKREGFPNLGNTCYMNSILQSVFGIPTFAKDLLTQGIPWEKVSYDDLIMPLSQLLVLKDIRDVEIKGELLTSVKKSISTVADTFSGNEQNDAHEFLSLCLDQLKL NMEKVNAMWDTERRNTCAGSAGTKRFVCPVGANFEFELHSSIICEGCGEATIKTEVSNYLSIDLHHGTKTHPLSIQKSFDLFFTPEKIEHNCEKCKNKNSVLKYTLRRLPRVLIVHLKRYQVTTDLLPVK SEQPVEISKYLNISSHCHENRKLPFPLANTSPDVSQGMMPGIFNQSMLSKKVISESCDPMVLQVGSSVDAEIQSFQIMYEDEDASEEQQQRGLESGSMLEPELVKTENRILRQKTSLATDSMMGDGYSFL PMLCEPLSIQDPGLAEMGLQEVPENPEFKNYEKINIYGKSDGRTNTELSKLYQNHGSRIKGLFLPASLASVSSQEDPEKDLSRSPELQEDDPHSFAFGSDDSKDGEMGDDLQNYRLVSVVSHFGSSPNSG HYVSDVYDFQKQAWLLYSDVQVFESSDPSIQENRLNSGYIFFYMHNEIFEELLKKASECKVLSTSKEEKRDIDYFSTLLNGLTYILEEF

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:32457395}. Note=Localizes to perinuclear region in response to herpes simplex virus-1 (HSV-1) infection. {Experimental EvidencePubMed:32457395}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Deubiquitinase involved in innate antiviral immunity by mediating 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization. {Experimental EvidencePubMed:32457395}.
Assigned Ontology terms

Biological Process	Defense Response To Virus (GO:0051607) G1/S Transition Of Mitotic Cell Cycle (GO:0000082) Innate Immune Response (GO:0045087) Positive Regulation Of Type I Interferon-Mediated Signaling Pathway (GO:0060340) Protein Deubiquitination (GO:0016579) Protein K48-Linked Deubiquitination (GO:0071108) Protein Stabilization (GO:0050821) Ubiquitin-Dependent Protein Catabolic Process (GO:0006511)
Molecular Function	Cysteine-Type Deubiquitinase Activity (GO:0004843) Cysteine-Type Endopeptidase Activity (GO:0004197)

Cross-References

Database	Links
UNIPROT	Q9ES63 C6EQG1
Pfam	PF00443 PF16674
PROSITE	PS00972 PS00973 PS50235

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK