C-Jun-amino-terminal kinase-interacting protein 3 - Mus musculus

C-Jun-amino-terminal kinase-interacting protein 3 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	C-Jun-amino-terminal kinase-interacting protein 3
Accession Code	Q9ESN9
Gene	Mapk8ip3
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1337)
MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVEL ELLREDNEQLLTQYEREKALRKQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE YNALHQRHTEMIQTYVEHIERSKMQQVGGSGQTESSLPGRSRKERPTSLNVFPLADGMVRAQMGGKLVPAGDHWHLSDLG QLQSSSSYQCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYVSVTKNNKQAREKRNSRNMEV QVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPETRLERTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDE GADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLKGELEAAKQAKVKLENRIKEL EEELKRVKSEAVTARREPREEVEDVSSYLCTELDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR EHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRSYPSVNIHYKSPTAAGFSQRRSHALCQISAGSRPLEFFPDDDCTSSAR REQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPSTKLWCAAGVNLSGWK PHEEDSSNGPKPVPGRDPLTCDREGEGEPKSTHPSPEKKKAKETPEADATSSRVWILTSTLTTSKVVIIDANQPGTIVDQ FTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGDVA TTANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTPSSSTQPASENGSESNGTIVQPQVEPSGE LSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHL MDLGHPHHSIRCMAVVNDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTH QHLQDVDIEPYVSKMLGTGKLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTR PGGIIHVYGDDSSDKAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKL KNALVLSGGEGYIDFRIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQVSYTPE

Structure Viewer (PDB: 6EJN)

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:10629060}. Golgi apparatus {Experimental EvidencePubMed:11106729}. Cytoplasmic vesicle {Experimental EvidencePubMed:11106729}. Cell projection, growth cone {Experimental EvidencePubMed:10629060}. Cell projection, axon {ECO:0000269\|PubMed:25944905}. Cell projection, dendrite {ECO:0000250\|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells (PubMed:10629060, PubMed:11106729). KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation (By similarity). {ECO:0000250\|UniProtKB:E9PSK7, Experimental EvidencePubMed:10629060, Experimental EvidencePubMed:11106729}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Axolemma (GO:0030673) Axon (GO:0030424) Axon Cytoplasm (GO:1904115) Cell Body (GO:0044297) Cytoplasm (GO:0005737) Cytoplasmic Vesicle (GO:0031410) Dendrite (GO:0030425) Golgi Membrane (GO:0000139) Growth Cone (GO:0030426) Neuron Projection (GO:0043005) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Smooth Endoplasmic Reticulum (GO:0005790)

Biology & Function

Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553). {Experimental EvidencePubMed:10523642, Experimental EvidencePubMed:10629060, Experimental EvidencePubMed:23576431, Experimental EvidencePubMed:25944905, Experimental EvidencePubMed:28259553}.
Assigned Ontology terms

Biological Process	Anterograde Axonal Protein Transport (GO:0099641) Axon Development (GO:0061564) Axon Guidance (GO:0007411) Axon Regeneration (GO:0031103) Forebrain Development (GO:0030900) In Utero Embryonic Development (GO:0001701) JNK Cascade (GO:0007254) Lung Alveolus Development (GO:0048286) Lung Morphogenesis (GO:0060425) Negative Regulation Of Apoptotic Process (GO:0043066) Positive Regulation Of JNK Cascade (GO:0046330) Positive Regulation Of JUN Kinase Activity (GO:0043507) Positive Regulation Of Neuron Differentiation (GO:0045666) Positive Regulation Of Neuron Migration (GO:2001224) Post-Embryonic Development (GO:0009791) Protein Localization (GO:0008104) Protein Stabilization (GO:0050821) Regulation Of Gene Expression (GO:0010468) Regulation Of JNK Cascade (GO:0046328) Respiratory Gaseous Exchange By Respiratory System (GO:0007585) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	JUN Kinase Binding (GO:0008432) Kinesin Binding (GO:0019894) MAP-Kinase Scaffold Activity (GO:0005078) Mitogen-Activated Protein Kinase Kinase Binding (GO:0031434) Mitogen-Activated Protein Kinase Kinase Kinase Binding (GO:0031435) Signaling Receptor Complex Adaptor Activity (GO:0030159)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q9ESN9	Self	EBI-7017786	0.40
Q9UQF2	C-Jun-amino-terminal kinase-interacting protein 1	EBI-7017807	0.40
Interactions with other proteins (17 interactors)

Partner (UniProt)		IntAct	Confidence score
O88448	Kinesin light chain 2 (KLC 2)	EBI-297849	0.68
O88447	Kinesin light chain 1 (KLC 1)	EBI-297849	0.72
P63101	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)	EBI-2255635	0.35
P62331	ADP-ribosylation factor 6 (EC 3.6.5.2)	EBI-7986308	0.60
P28738	Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)	EBI-7017356	0.59
Q9ERE9	C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)	EBI-7017828	0.40
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-6530187	0.40
Q61831	Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)	EBI-9549479	0.54
Q9WTU6	Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)	EBI-9549854	0.40
Q91Y86	Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)	EBI-9549815	0.40
P47809	Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1)	EBI-9549947	0.50
P31938	Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)	EBI-9550942	0.50
P53349	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)	EBI-9550988	0.50
P04049	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)	EBI-9637077	0.50
O88704	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)	EBI-16730213	0.35
Q80VP2	Spermatogenesis-associated protein 7 homolog	EBI-21018622	0.35
P16056	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	EBI-27118288	0.35

Cross-References

Database	Links
UNIPROT	Q9ESN9 Q5D062 Q99KU7 Q9EQD8 Q9ESN7 Q9ESN8 Q9ESP0 Q9JLH2 Q9JLH3 Q9R0U7
PDB	6EJN
Pfam	PF16471 PF09744
PROSITE	PS51776 PS51777

C-Jun-amino-terminal kinase-interacting protein 3 (Mus musculus)

General Information

Protein Information

Structure Viewer (PDB: 6EJN)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Interactions with other proteins (17 interactors)

Cross-References

Database

Links

Description

Description