NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ribonuclease TUDOR 2 - Arabidopsis thaliana - NucEnvDB

Ribonuclease TUDOR 2 (Arabidopsis thaliana)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Ribonuclease TUDOR 2
Accession Code	Q9FLT0
Gene	TSN2
Organism	Arabidopsis thaliana \| Thale cress (Taxonomy: 3702)
Part of Reference Proteome?	Yes
Sequence (Length: 985)
MATGAATENQWLKGRVKAVTSGDCLVITALTHNRAGPPPEKTITLSSLMAPKMARRGGIDEPFAWESREFLRKLCIGKEVAFKVDYKVEAIAGREFGSVYLGNENLAKLVVQNGWAKVRRPGQQNQDKVS PYIAELEQLEEQAQQEGFGRWSKVPGAAEASIRNLPPSAVGDSGNFDAMGLLAASKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGLQAPSMGRRQSTQEAVVDPDVTATSNGDASAETRGPLTTA QRLAASAASSVEVSSDPFAMEAKYFTELRVLNRDVRIVLEGVDKFNNLIGSVYYSDGDTVKDLGLELVENGLAKYVEWSANMLDEEAKKKLKATELQCKKNRVKMWANYVPPASNSKAIHDQNFTGKVVE VVSGDCLVVADDSIPFGSPMAERRVCLSSIRSPKMGNPRREEKPAPYAREAKEFLRQKLIGMEVIVQMEYSRKISPGDGVTTSGAGDRVMDFGSVFLPSPTKGDTAVAAAATPGANIAELIISRGLGTVV RHRDFEERSNHYDALLAAEARAIAGKKNIHSAKDSPALHIADLTVASAKKAKDFLPSLQRINQISAVVEYVLSGHRFKLYIPKESCSIAFAFSGVRCPGRGEPYSEEAIALMRRKIMQRDVEIVVENVDR TGTFLGSMWEKNSKTNAGTYLLEAGLAKMQTGFGADRIPEAHILEMAERSAKNQKLKIWENYVEGEEVVNGSSKVETRQKETLKVVVTEVLGGGRFYVQTVGDQKVASIQNQLAALSLKDAPIIGSFNPK KGDIVLAQFSLDNSWNRAMIVNGPRGAVQSPEEEFEVFYIDYGNQEIVPYSAIRPVDPSVSSAPGLAQLCRLAYIKVPGKEEDFGRDAGEYLHTVTLESGKEFRAVVEERDTSGGKVKGQGTGTELVVTL IAVDDEISVNAAMLQEGIARMEKRRRWEPKDKQAALDALEKFQDEARKSRTGIWEYGDIQSDDEDNVPVRKPGRG

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:20484005, Experimental EvidencePubMed:25736060}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:20484005}. Endoplasmic reticulum {Experimental EvidencePubMed:20484005}. Cytoplasmic granule {Experimental EvidencePubMed:25736060}. Note=Accumulates heterogeneously in the cytosol, in patches around the nucleus and in the cell periphery, and relocates transiently to a diffuse pattern in response to salt stress (PubMed:20484005). Accumulates in cytoplasmic stress granules (SGs) and processing bodies (PBs) in response to abiotic stresses (e.g. salt and heat) (PubMed:25736060). {Experimental EvidencePubMed:20484005, Experimental EvidencePubMed:25736060}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoplasmic Stress Granule (GO:0010494) Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Nuclear Envelope (GO:0005635) Nucleus (GO:0005634) P-Body (GO:0000932) Perinuclear Region Of Cytoplasm (GO:0048471) Plasmodesma (GO:0009506) Plastid (GO:0009536) RISC Complex (GO:0016442)

Biology & Function

Description
Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress (PubMed:25736060). Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat) (PubMed:25736060). Involved in gibberellic acid (GA) biosynthesis and seed germination (PubMed:20396901). Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway (PubMed:20484005). Component of stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20OX3 mRNA. Binds GA20OX3 mRNA (By similarity). May inhibit the degradation of mRNAs involved in stress adaptation (PubMed:26237081). {By SimilarityUniProtKB:Q8VZG7, Experimental EvidencePubMed:20396901, Experimental EvidencePubMed:20484005, Experimental EvidencePubMed:25736060, Experimental EvidencePubMed:26237081}.
Assigned Ontology terms

Biological Process	Cellular Response To Heat (GO:0034605) RNA-Mediated Gene Silencing (GO:0031047) Gibberellin Biosynthetic Process (GO:0009686) MRNA Catabolic Process (GO:0006402) MRNA Processing (GO:0006397) Positive Regulation Of Gibberellin Biosynthetic Process (GO:0010372) Response To Cadmium Ion (GO:0046686) Response To Salt Stress (GO:0009651) Seed Germination (GO:0009845)
Molecular Function	MRNA Binding (GO:0003729) Nuclease Activity (GO:0004518) RNA Binding (GO:0003723)

Cross-References

Database	Links
UNIPROT	Q9FLT0 Q0WLY7 Q0WM01 Q0WVT1
Pfam	PF00565 PF00567
PROSITE	PS50830 PS50304

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