NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Sodium channel protein type 5 subunit alpha - Mus musculus - NucEnvDB

Sodium channel protein type 5 subunit alpha (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Sodium channel protein type 5 subunit alpha
Accession Code	Q9JJV9
Gene	Scn5a
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 2019)
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSATSQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVH SLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFC LSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTNHERRSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSM RPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCA DGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG WNIFDSIIVILSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCME VSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEKAPPARKETRFEEDKRPGQGT PGDTEPVCVPIAVAESDTDDQEEDEENSLGTEEEESSKQESQVVSGGHEPPQEPRAWSQVSETTSSEAEASTSQADWQQEREAEPRAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCF TEGCVRRCPCCMVDTTQAPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA VDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVN ILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGI DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFA DALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQRSVKHASFLFRQQAGSSGLSDEDAPEREGL IAYMMNENFSRRSGPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSRSEDLADFPPSPDRDRESIV

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:11834499, Experimental EvidencePubMed:23420830}; Multi-pass membrane protein {By SimilarityUniProtKB:D0E0C2}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q14524}. Cell membrane, sarcolemma, T-tubule {By SimilarityUniProtKB:P15389}. Note=RANGRF promotes trafficking to the cell membrane. {Experimental EvidencePubMed:23420830}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	By Similarity {ECO:0000250\|UniProtKB:D0E0C2}
Assigned Ontology terms

Cellular Component	Caveola (GO:0005901) Cell Surface (GO:0009986) Endoplasmic Reticulum (GO:0005783) Intercalated Disc (GO:0014704) Lateral Plasma Membrane (GO:0016328) Nucleolus (GO:0005730) Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Sarcolemma (GO:0042383) Sodium Channel Complex (GO:0034706) T-Tubule (GO:0030315) Voltage-Gated Sodium Channel Complex (GO:0001518) Z Disc (GO:0030018)

Biology & Function

Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:11834499, PubMed:23420830). It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity). {By SimilarityUniProtKB:Q14524, Experimental EvidencePubMed:11834499, Experimental EvidencePubMed:23420830}.
Assigned Ontology terms

Biological Process	Atrial Cardiac Muscle Cell Action Potential (GO:0086014) AV Node Cell Action Potential (GO:0086016) AV Node Cell To Bundle Of His Cell Communication (GO:0086067) Bundle Of His Cell Action Potential (GO:0086043) Cardiac Muscle Cell Action Potential Involved In Contraction (GO:0086002) Cardiac Muscle Contraction (GO:0060048) Cardiac Ventricle Development (GO:0003231) Cellular Response To Calcium Ion (GO:0071277) Membrane Depolarization (GO:0051899) Membrane Depolarization During Action Potential (GO:0086010) Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential (GO:0098912) Membrane Depolarization During AV Node Cell Action Potential (GO:0086045) Membrane Depolarization During Bundle Of His Cell Action Potential (GO:0086048) Membrane Depolarization During Cardiac Muscle Cell Action Potential (GO:0086012) Membrane Depolarization During Purkinje Myocyte Cell Action Potential (GO:0086047) Membrane Depolarization During SA Node Cell Action Potential (GO:0086046) Neuronal Action Potential (GO:0019228) Positive Regulation Of Action Potential (GO:0045760) Positive Regulation Of Epithelial Cell Proliferation (GO:0050679) Positive Regulation Of Heart Rate (GO:0010460) Positive Regulation Of Sodium Ion Transport (GO:0010765) Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization (GO:0060371) Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization (GO:0060372) Regulation Of Cardiac Muscle Cell Contraction (GO:0086004) Regulation Of Heart Rate (GO:0002027) Regulation Of Heart Rate By Cardiac Conduction (GO:0086091) Regulation Of Sodium Ion Transmembrane Transport (GO:1902305) Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization (GO:0060373) Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization (GO:0060307) Response To Denervation Involved In Regulation Of Muscle Adaptation (GO:0014894) Response To Organic Cyclic Compound (GO:0014070) SA Node Cell Action Potential (GO:0086015) Sodium Ion Import Across Plasma Membrane (GO:0098719) Sodium Ion Transmembrane Transport (GO:0035725) Sodium Ion Transport (GO:0006814) Ventricular Cardiac Muscle Cell Action Potential (GO:0086005)
Molecular Function	Ankyrin Binding (GO:0030506) Calmodulin Binding (GO:0005516) Enzyme Binding (GO:0019899) Fibroblast Growth Factor Binding (GO:0017134) Nitric-Oxide Synthase Binding (GO:0050998) Protein Domain Specific Binding (GO:0019904) Protein Kinase Binding (GO:0019901) Scaffold Protein Binding (GO:0097110) Transmembrane Transporter Binding (GO:0044325) Ubiquitin Protein Ligase Binding (GO:0031625) Voltage-Gated Ion Channel Activity (GO:0005244) Voltage-Gated Sodium Channel Activity (GO:0005248) Voltage-Gated Sodium Channel Activity Involved In AV Node Cell Action Potential (GO:0086060) Voltage-Gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential (GO:0086061) Voltage-Gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential (GO:0086006) Voltage-Gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential (GO:0086062) Voltage-Gated Sodium Channel Activity Involved In SA Node Cell Action Potential (GO:0086063)

Protein-Protein Interactions

Interactions with other proteins (4 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Z0J4	Nitric oxide synthase, brain (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (bNOS)	EBI-15712165	0.35
Q6Q477	Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10)	EBI-15712165	0.35
Q61234	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin-1)	EBI-15712165	0.35
Q4U4S6	Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Myogenic MEF2-activated Xin-related protein) (Myomaxin) (mXinbeta)	EBI-26520955	0.40

Cross-References

Database	Links
UNIPROT	Q9JJV9 E9Q1D2 Q3UH91
Pfam	PF00520 PF06512 PF11933

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