NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Calcium-binding protein 2 - Mus musculus - NucEnvDB

Calcium-binding protein 2 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Calcium-binding protein 2
Accession Code	Q9JLK4
Gene	Cabp2
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 216)
MGNCAKTPWHRGSKERWQWPGSPLGGSRPSPGPRTEEQEGTQGYSVLGSLVGPACIFLRPSIAATQLDRELRPEEIEELQIAFQEFDRDRDGYIGYRELGACMRTLGYMPTEMELIEISQQISGGKVDFE DFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISVGELRAALKALLGERLSQREVDEILQDIDLNGDGLVDFEEFVRMMSR

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Cell membrane {By Similarity}; Lipid-anchor {By Similarity}; Cytoplasmic side {By Similarity}. Golgi apparatus {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Golgi Apparatus (GO:0005794) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs (PubMed:28183797). Required for the normal transfer of light signals through the retina (PubMed:27822497). {Experimental EvidencePubMed:27822497, Experimental EvidencePubMed:28183797}.
Assigned Ontology terms

Biological Process	Regulation Of Voltage-Gated Calcium Channel Activity (GO:1901385) Response To Stimulus (GO:0050896) Sensory Perception Of Sound (GO:0007605) Visual Perception (GO:0007601)
Molecular Function	Calcium Channel Regulator Activity (GO:0005246) Calcium Ion Binding (GO:0005509)

Cross-References

Database	Links
UNIPROT	Q9JLK4 Q3KNX9 Q9JLK5
Pfam	PF00036 PF13499
PROSITE	PS00018 PS50222

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