National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Prostaglandin E synthase 2 truncated form |
| Accession Code | Q9N0A4 |
| Gene | PTGES2 |
| Organism | Macaca fascicularis | Crab-eating macaque (Taxonomy: 9541) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 377) |
Structure Viewer (PDB: 1Z9H) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
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|---|---|
| Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:11866447, PubMed:23426368). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:23426368). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:23426368). {Experimental EvidencePubMed:11866447, Experimental EvidencePubMed:23426368}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | Q9N0A4 Q5DI73 |
| PDB | 1Z9H 2PBJ |
| Pfam | PF13417 |
| PROSITE | PS00195 PS51354 PS50405 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory