NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Leupaxin - Oryctolagus cuniculus - NucEnvDB

Leupaxin (Oryctolagus cuniculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Leupaxin
Accession Code	Q9N261
Gene	LPXN
Organism	Oryctolagus cuniculus \| Rabbit (Taxonomy: 9986)
Part of Reference Proteome?	Yes
Sequence (Length: 386)
MEELDALLEELERSTLQDSDEYSNSAPLPLDQSSRKESNLDETSKMLSVQDSTNPFPVQLVYTTNIQDRNVYSEVQEPKKSPPPAKTSAAAQLDELMAHLSEMQAKVSVKADAGKKPVSENLDHKASLDS MLGGLEQELQNLGIPTVPKGHCASCQKPIVGKVIHALGQSWHPEHFICTHCKEEIGSSPFFERSGLAYCPKDYHHLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGTEGFHEKDKKPYCRK DFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSTGSFFELEGRPFCELHYHQRRGTLCHGCGQPITGRCISAMGHKFHPEHFVCAFCLTQLSKGVFREQNDKTYCQPCFNKLFSL

Subcellular Location

Description
Cytoplasm {By Similarity}. Cell junction, focal adhesion {By Similarity}. Nucleus {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Cell projection, podosome {By Similarity}. Cell membrane {By Similarity}. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Projection (GO:0042995) Focal Adhesion (GO:0005925) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Podosome (GO:0002102)

Biology & Function

Description
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Cell Adhesion (GO:0007155)
Molecular Function	Metal Ion Binding (GO:0046872)

Cross-References

Database	Links
UNIPROT	Q9N261 G1TMN6
Pfam	PF00412
PROSITE	PS00478 PS50023

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