National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Serine/threonine-protein kinase chk-1 |
| Accession Code | Q9N3Z3 |
| Gene | chk |
| Organism | Caenorhabditis elegans (Taxonomy: 6239) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 503) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
|
|---|---|
| Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:15326393). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:15326393). Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells (PubMed:15326393, PubMed:27956467). Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae (PubMed:26073019). Essential for embryogenesis (PubMed:15326393). {Experimental EvidencePubMed:15326393, Experimental EvidencePubMed:26073019, Experimental EvidencePubMed:27956467}. | Assigned Ontology terms |
Interactions with other proteins (2 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q9N3Z3 Q17375 Q86FM7 |
| Pfam | PF00069 |
| PROSITE | PS00107 PS50011 PS00108 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory