The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs).
Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution (PubMed:28122936). {By
SimilarityUniProtKB:P55735, Experimental EvidencePubMed:28122936}. As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. {By
SimilarityUniProtKB:P55735}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory