NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Lissencephaly-1 homolog - Caenorhabditis elegans - NucEnvDB

Lissencephaly-1 homolog (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Lissencephaly-1 homolog
Accession Code	Q9NDC9
Gene	lis
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 404)
MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATI KVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASLDQTVTVW SFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPEGNSTHILFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVI TGSVDMSCKVWECR

Subcellular Location

Description
Cytoplasm, cytoskeleton {Sequence AnalysisHAMAP- Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {Sequence AnalysisHAMAP-Rule:MF_03141}. Chromosome, centromere, kinetochore {Curator Inference}. Nucleus envelope {Curator Inference\|PubMed:20005871}. Note=Localizes to the plus end of microtubules (By similarity). Concentrates in the vicinity of microtubule asters, kinetochores, the cell cortex and the perinuclear region (PubMed:15331665). Probably recruited to the nuclear envelope by unc-83 (PubMed:20005871). {By SimilarityUniProtKB:P63004, Experimental EvidencePubMed:15331665, Curator Inference\|PubMed:20005871}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Aster (GO:0005818) Axon Cytoplasm (GO:1904115) Cell Cortex (GO:0005938) Cytoplasm (GO:0005737) Cytoplasmic Dynein Complex (GO:0005868) Cytoplasmic Microtubule (GO:0005881) Kinetochore (GO:0000776) Microtubule (GO:0005874) Microtubule Associated Complex (GO:0005875) Microtubule Organizing Center (GO:0005815) Neuron Projection (GO:0043005) Neuronal Cell Body (GO:0043025) Nuclear Envelope (GO:0005635) Perinuclear Region Of Cytoplasm (GO:0048471) Synapse (GO:0045202)

Biology & Function

Description
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division (PubMed:11685578, PubMed:15331665). Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). Required for neuronal cell differentiation (PubMed:15254012). {Sequence AnalysisHAMAP-Rule:MF_03141, Experimental EvidencePubMed:11685578, Experimental EvidencePubMed:15254012, Experimental EvidencePubMed:15331665, Experimental EvidencePubMed:16996038, Experimental EvidencePubMed:20005871}.
Assigned Ontology terms

Biological Process	Brain Morphogenesis (GO:0048854) Cell Division (GO:0051301) Chiasma Assembly (GO:0051026) Embryo Development Ending In Birth Or Egg Hatching (GO:0009792) Engulfment Of Apoptotic Cell (GO:0043652) Establishment Of Mitotic Spindle Orientation (GO:0000132) Germ Cell Development (GO:0007281) Locomotion (GO:0040011) Maintenance Of Centrosome Location (GO:0051661) Microtubule Organizing Center Organization (GO:0031023) Microtubule Sliding (GO:0051012) Microtubule-Based Movement (GO:0007018) Mitotic Centrosome Separation (GO:0007100) Nuclear Migration (GO:0007097) Nuclear Migration Along Microfilament (GO:0031022) Oogenesis (GO:0048477) Pronuclear Migration (GO:0035046) Retrograde Axonal Transport (GO:0008090) Spindle Assembly (GO:0051225) Synaptic Transmission, GABAergic (GO:0051932) Synaptic Vesicle Transport (GO:0048489) Vesicle Transport Along Microtubule (GO:0047496)
Molecular Function	Dynein Complex Binding (GO:0070840) Microtubule Plus-End Binding (GO:0051010)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P13508	Protein glp-1 [Cleaved into: glp-1/Notch intracellular domain]	EBI-6456381	0.37
P91001	COP9 signalosome complex subunit 5 (Signalosome subunit 5) (EC 3.4.-.-) (JAB1 homolog)	EBI-6460941	0.37

Cross-References

Database	Links
UNIPROT	Q9NDC9 O45742
Pfam	PF08513 PF00400
PROSITE	PS50896 PS00678 PS50082 PS50294

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