NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Probable ATP-dependent RNA helicase DDX4 - Homo sapiens - NucEnvDB

Probable ATP-dependent RNA helicase DDX4 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Probable ATP-dependent RNA helicase DDX4
Accession Code	Q9NQI0
Gene	DDX4
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 724)
MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWRESSNDCEDNPTRNRGFSKR GGYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPNNDLDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPEDEDSIFA HYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQIYLEARKFSF GTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVL QVGQFSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDN HLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTRGNVFASVDTRKGKSTLNTAGFSSSQAPNPVDDESWD

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q61496}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q61496}. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. {By SimilarityUniProtKB:Q61496}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) P Granule (GO:0043186) Perinuclear Region Of Cytoplasm (GO:0048471) Pi-Body (GO:0071546) PiP-Body (GO:0071547)

Biology & Function

Description
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing- triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity). {By SimilarityUniProtKB:Q61496, Experimental EvidencePubMed:10920202, Experimental EvidencePubMed:21034600}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) DNA Methylation Involved In Gamete Generation (GO:0043046) Flagellated Sperm Motility (GO:0030317) Gamete Generation (GO:0007276) RNA-Mediated Gene Silencing (GO:0031047) Male Meiosis I (GO:0007141) Male Meiotic Nuclear Division (GO:0007140) Negative Regulation Of Transposition (GO:0010529) PiRNA Processing (GO:0034587) Spermatogenesis (GO:0007283)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Molecular Condensate Scaffold Activity (GO:0140693) RNA Binding (GO:0003723) RNA Helicase Activity (GO:0003724)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P12931	Proto-oncogene tyrosine-protein kinase Src	EBI-7609853	0.40
Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8JPQ9	Non-structural protein NS-S	EBI-6159460	0.35
Q86VP6	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)	EBI-21322532	0.35
Q96GG9	DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)	EBI-21325177	0.35
Q13618	Cullin-3 (CUL-3)	EBI-21329068	0.35
Q9NZ43	Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31)	EBI-10887976	0.35
Q9Y2H1	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2)	EBI-20624829	0.27

Cross-References

Database	Links
UNIPROT	Q9NQI0 A8K8Q2 B3KSF4 D6RDK4 E9PCD8 Q5M7Z3 Q86VX0 Q9NT92 Q9NYB1
Pfam	PF00270 PF00271
PROSITE	PS00039 PS51192 PS51194 PS51195
OMIM	605281
DisGeNET	54514

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