The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Receptor for the leucine-rich nuclear export signal (NES) (PubMed:10636888, PubMed:14638854, PubMed:16103875). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form (PubMed:10636888, PubMed:14638854). Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm (PubMed:14638854, PubMed:25858587, PubMed:17032737). Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae (PubMed:31626769). Required for the function or maintenance of certain tissues such as brain and gut (PubMed:10924475). {Experimental EvidencePubMed:10636888, Experimental EvidencePubMed:10924475, Experimental EvidencePubMed:14638854, Experimental EvidencePubMed:17032737, Experimental EvidencePubMed:25858587, Experimental EvidencePubMed:31626769}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory