Protein spire - Drosophila melanogaster

Protein spire (Drosophila melanogaster)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Protein spire
Accession Code	Q9U1K1
Gene	spir
Organism	Drosophila melanogaster (Taxonomy: 7227)
Part of Reference Proteome?	Yes
Sequence (Length: 1020)
MTEHQAEEQADTPPTKVKATPTPTPSGKFKDAKEDAFLSTSPDSANGDAQHKLPADQLAMSSSAHPQQAGQARPLILQAF HRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQFAGLYHQVAVQAHTCAADYEAALPTGFELHFHRDGSVHFSGPDQLT PKEQLQQEQIPLPPQHDVIVDQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLP EDEECQVSQELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEERNDTKELEHIIETCRNHIKTTLPENHYRAVCRAL VTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVIDELRRGVRLKKSNHERTPIEYELTPY EILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQI TPPEAPTLRERVLPSANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPFG GYMVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSFTKDEYHKFYDTALESYDLATQCESRRASLRRHTIVGCQSNL DETHSMPPTRPESRQSDDVSKETPKRSPAEQTHPSDEGSSTSSLGPWNKSFMDKQTWMERGDDRLSVTLAEIVHIRSVMT KAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVLISPSLLSSPA SSSTPSPSHHAQQAHSSSTGNIMDDQFPKSLIERLLRSESDRKTRSTVGSAPSSPKHQRSNMSTPGISVGPGASSSSAAA TGQAVEALHDQATMSSSYSAAMRPSGVHQQQKQHYNNAMSRSMEGPRSLPVHSPAYRPLSNNSTLERKSRFSRGFNLFSS GSHLAQTQEQKENLRGEQVTVCNDCQGLVNEITSSVKQKRSSARNRTIQNLTLDLTPVWK

Structure Viewer (PDB: 3MMV)

Subcellular Location

Description
Cytoplasm, cytoskeleton {Experimental EvidencePubMed:10744979}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:10744979}. Cell membrane {ECO:0000269\|PubMed:21730168}; Peripheral membrane protein {ECO:0000269\|PubMed:21730168}; Cytoplasmic side {ECO:0000269\|PubMed:21730168}. Cytoplasmic vesicle membrane {ECO:0000269\|PubMed:21730168}; Peripheral membrane protein {ECO:0000269\|PubMed:21730168}; Cytoplasmic side {ECO:0000269\|PubMed:21730168}. Note=Punctate spots in perinuclear region and cytoplasm. {Experimental EvidencePubMed:10744979}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Experimental Evidence {ECO:0000269\|PubMed:21730168}
Assigned Ontology terms

Cellular Component	Cell Cortex (GO:0005938) Cytoplasm (GO:0005737) Cytoplasmic Vesicle Membrane (GO:0030659) Cytoskeleton (GO:0005856) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton. {Experimental EvidencePubMed:10556052, Experimental EvidencePubMed:10744979, Experimental EvidencePubMed:15674283, Experimental EvidencePubMed:20538977, Experimental EvidencePubMed:21730168}.
Assigned Ontology terms

Biological Process	Actin Cytoskeleton Organization (GO:0030036) Actin Filament Network Formation (GO:0051639) Actin Filament Organization (GO:0007015) Actin Filament Polymerization (GO:0030041) Actin Filament-Based Process (GO:0030029) Actin Nucleation (GO:0045010) Chorion-Containing Eggshell Formation (GO:0007304) Cleavage Furrow Formation (GO:0036089) Establishment Of Meiotic Spindle Localization (GO:0051295) Golgi Vesicle Transport (GO:0048193) Intracellular Transport (GO:0046907) Oocyte Karyosome Formation (GO:0030717) Oogenesis (GO:0048477) Polar Body Extrusion After Meiotic Divisions (GO:0040038) Pole Plasm Assembly (GO:0007315) Pole Plasm Oskar MRNA Localization (GO:0045451) Pole Plasm RNA Localization (GO:0007316) Protein Transport (GO:0015031) Regulation Of Cytoskeleton Organization (GO:0051493) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	Actin Binding (GO:0003779) Microtubule Binding (GO:0008017)

Protein-Protein Interactions

Interactions with other proteins (22 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9VRF5	IP09483p	EBI-197814	0.00
Q7K159	LD06557p (Myb-interacting protein 40)	EBI-197818	0.00
Q7JQ36	Receptor protein serine/threonine kinase (EC 2.7.11.30)	EBI-197822	0.00
Q9VBN2	Lipophorin receptor 2, isoform A	EBI-197831	0.00
P92208	Stress-activated protein kinase JNK (dJNK) (EC 2.7.11.24) (Protein basket)	EBI-871706	0.50
P08736	Elongation factor 1-alpha 1 (EF-1-alpha-1) (50 kDa female-specific protein)	EBI-197839	0.00
Q9VHS2	Cytochrome c oxidase subunit 7A, mitochondrial (Cytochrome c oxidase subunit VIIa)	EBI-197843	0.00
Q9VFP2	Protein roadkill (Hh-induced MATH and BTB domain-containing protein)	EBI-197847	0.00
Q9XYZ4	Double-strand break repair protein	EBI-509448	0.00
P10987	Actin-5C (EC 3.6.4.-)	EBI-15859640	0.76
P40793	Cdc42 homolog (EC 3.6.5.2)	EBI-871870	0.27
P40792	Ras-related protein Rac1	EBI-874148	0.27
P48148	Ras-like GTP-binding protein Rho1	EBI-874192	0.27
Q95RI5	Failed axon connections	EBI-9941865	0.50
Q99323	Myosin heavy chain, non-muscle (Myosin II) (Non-muscle MHC) (Zipper protein)	EBI-9942589	0.35
Q9W542	LD07342p (Myb-interacting protein 130)	EBI-9942822	0.35
Q9VSW1	UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)	EBI-9943131	0.35
Q9VH81	Protein-serine/threonine phosphatase (EC 3.1.3.16)	EBI-9948351	0.35
Q8INK3	Fatty acid binding protein, isoform C	EBI-9964589	0.35
Q9VHP0	ATP-dependent RNA helicase bel (EC 3.6.4.13) (Protein belle)	EBI-9966138	0.35
Q9VZP5	Eukaryotic translation initiation factor 5B (Translation initiation factor IF-2)	EBI-9967416	0.35
P68135	Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]	EBI-15859700	0.81

Cross-References

Database	Links
UNIPROT	Q9U1K1 Q5U0Z8 Q8INV3 Q8INV4 Q8INV5 Q8SXP3 Q8T8P8 Q9U4F0 Q9U4F1 Q9VIN3 Q9VIN4
PDB	3MMV 3MN5 3MN6 3MN7 3MN9 3UE5 4EFH
Pfam	PF16474
PROSITE	PS51377 PS51082

NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein spire (Drosophila melanogaster)

General Information

Protein Information

Structure Viewer (PDB: 3MMV)

Subcellular Location

Description

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description

Assigned Ontology terms

Protein-Protein Interactions

Interactions with other proteins (22 interactors)

Cross-References

Database

Links

Protein spire (Drosophila melanogaster)

General Information

Protein Information

Structure Viewer (PDB: 3MMV)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with other proteins (22 interactors)

Cross-References

Database

Links

Description

Description