The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Involved in mRNA export and mRNA coupled transcription activation (PubMed:18034162, PubMed:27016737, PubMed:33602059). Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:18034162, PubMed:27016737). The TREX-2/AMEX complex also functions with the transcriptional coactivator SAGA/TFTC complex, to anchor a subset of transcription sites to the nuclear pore complex basket in order to achieve efficient transcription and export of their resulting mRNAs (PubMed:18034162). Within the complex, required for localization of e(y)2 to the nuclear periphery (PubMed:18034162). {Experimental EvidencePubMed:18034162, Experimental EvidencePubMed:27016737, Experimental EvidencePubMed:33602059}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory