National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Ran GTPase-activating protein |
| Accession Code | Q9VIW3 |
| Gene | RanGAP |
| Organism | Drosophila melanogaster (Taxonomy: 7227) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 596) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Membrane | SL-0182 | The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. | Membrane Topology |
| Topology | Source | Annotation Type |
| Peripheral | UniProt | Experimental Evidence {ECO:0000269|PubMed:17032737} | Assigned Ontology terms |
Description |
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|---|---|
| GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). {By SimilarityUniProtKB:Q684P5, Experimental EvidencePubMed:10073941, Experimental EvidencePubMed:31626769}. | Assigned Ontology terms |
Interactions with other proteins (7 interactors) |
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory